Bscl2 Antibody

1. there is a potential role of seipin in regulating autophagy in uterine luminal epithelium but not myometrium PMID: 29088395
2. we show that seipin knockdown had very little effect on adipocyte differentiation without affecting insulin sensitivity and oxygen consumption. PMID: 27748422
3. Although the severity of adipose loss in female and male Seipin(-/-)apoE(-/-) mice were similar, hyperlipidemia, steatohepatitis and atherosclerosis were less severe in females than in males. PMID: 29428127
4. These data identify SEIPIN as an evolutionarily conserved regulator of microsomal GPAT. PMID: 27806294
5. Seipin deficiency in astrocytes increases GSK3beta activity and levels of IL-6 and TNF-alpha through reducing PPARgamma, which can facilitate Abeta25-35/1-42-induced neuroinflammation to cause the death of neuronal cells and cognitive deficits. PMID: 27287266
6. Study found more nuclei positive for SEIPIN than shown using in situ hybridization and confirmed the presence of SEIPIN in neurons projecting to the spinal cord. PMID: 26621102
7. Findings reveal a key cell-autonomous role for BSCL2 in controlling brown adipose tissue mass and activity. PMID: 27185876
8. Our findings reveal that seipin knockout exacerbates cerebral I/R-induced damages by increasing BBB permeability, amplifying ER stress and increasing glucose levels, as well as decreasing leptin and adiponectin levels, indicating that seipin may be a potential therapeutic target for stroke. PMID: 27109482
9. The results indicate that, by reducing PPARgamma, seipin deficiency impairs proliferation and differentiation of neural stem and progenitor cells. PMID: 26398946
10. Authors generated adipose tissue (mature) Bscl2 knockout (Ad-mKO) mice to investigate the impact of acquired Bscl2 deletion on adipose tissue function and energy balance. PMID: 26269358
11. The present study provides in vivo evidence that neuronal seipin deficiency leads to spatial cognitive deficits thtat can be rescued by the activation of PPARgamma. PMID: 26818512
12. spermatid apoptosis, increased chromocenter fragmentation, abnormal acrosome formation, and defective mitochondrial activity contributed to decreased sperm production and defective sperm that resulted in Bscl2-/- male infertility. PMID: 26181198
13. Bscl2(-/-) females have accelerated postnatal mammary ductal development but delayed vaginal opening; they display segregated responses in mammary gland development and vaginal opening to prepubertal genistein treatment. PMID: 25462787
14. Using the lipodystrophic Seipin-deficient mouse (Seipin(-/-)) model, the study found Seipin(-/-) mice were unable to respond appropriately to a long time fasting and developed postprandial hypertriglyceridemia. PMID: 25866184
15. a brief overview of the genetic association of the CGLs, and focus on the current understanding of differential contributions of distinct seipin domains to lipid storage and adipogenesis. PMID: 25195639
16. Neuronal seipin deficiency causing reduced PPARgamma levels leads to affective disorders in male mice that are rescued by estradiol-increased PPARgamma expression. PMID: 24651066
17. New insights into the metabolic adaptations of liver in response to fasting and uncovered a novel fasting-dependent regulation of hepatic insulin signaling in a mouse model of human Berardinelli-Seip congenital lipodystrophy type 2. PMID: 25093462
18. other than being essential for adipocyte differentiation, Bscl2 is also important in fatty acid remodeling and energy homeostasis. PMID: 24358199
19. Our results therefore demonstrate a critical role of SEIPIN in maintaining lipid homeostasis and function of adipocytes and reveal an intimate relationship between SEIPIN and PPAR-gamma. PMID: 24622797
20. study proposes that seipin regulates adipogenesis by recruiting cofilin-1 to remodel actin cytoskeleton through the 14-3-3beta protein PMID: 24026679
21. Bscl2 deficiency in knockout mice is a model for Berardinelli-Seip congenital lipodystrophy in humans. [Review] PMID: 23831461
22. Here, we report teratozoospermia syndrome in a lipodystrophic patient with compound BSCL2 mutations, with sperm defects resembling the defects of infertile seipin null mutant mice. PMID: 24778225
23. These data demonstrate that Seipin-N88S mutation impairs synaptic neurotransmission PMID: 24345054
24. pathogenic Seipin-A212P inhibits adipogenesis and the inhibition is associated with activation of inflammatory pathways at pre-differentiation stages. PMID: 23520483
25. Seipin may be involved in lipid homoeostasis by restricting lipogenesis and lipid droplet accumulation in non-adipocytes, while promoting adipocyte formation to store excess lipid. PMID: 23458123
26. analysis of expression of the lipodystrophy and motor-neuropathy gene Bscl2 in adult mouse brain PMID: 23049863
27. These data suggest that Seipin regulates excitatory synaptic function through a post-synaptic mechanism. PMID: 23173741
28. Bscl2(-/-) mice develop severe lipodystrophy of white adipose tissue (WAT), dyslipidemia, insulin resistance, and hepatic steatosis. PMID: 22269949
29. the biochemical characteristics of seipin and its mis-sense mutants PMID: 21957196
30. Findings suggest a possible tissue-autonomous role of seipin in liver lipid storage. PMID: 21551454
31. seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology PMID: 18093937
32. Bscl2 is required for PPARgamma's full activation to initiate the adipogenesis transcription program. PMID: 19574402

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KEGG: mmu:14705

STRING: 10090.ENSMUSP00000127685

UniGene: Mm.345134