CDC5 Antibody

1. Cdc5 interacts with cohesin in vivo, and cohesin is required for association of Cdc5 at centromeric chromatin. Cohesin removal from centromeric chromatin requires Cdc5 but removal at distal chromosomal arm sites does not. Results define a novel role for Cdc5 in regulating removal of centromeric cohesins and faithful chromosome segregation. PMID: 27226485
2. Polo kinase Cdc5 mediates centrosome-dependent bypass of the DNA damage checkpoint. PMID: 26832404
3. Misregulated expression of Cdc5 causes increased mitotic crossover frequency. PMID: 23810555
4. Despite CDC5's central role in meiosis I, the protein kinase is dispensable during meiosis II and does not even phosphorylate its meiosis I targets during the second meiotic division PMID: 23918381
5. Our results reveal a role for Cdc5 in meiotic checkpoint control by regulating Ndt80 function PMID: 21795394
6. Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability. PMID: 21987786
7. Cdc5 acts to attenuate the DNA damage checkpoint through loss of Rad53 hyperphosphorylation to allow cells to adapt to DNA damage. PMID: 20126259
8. spindle pole body-associated Cdc5p activity is critical for both mitotic exit and cytokinesis, whereas the bud neck-localized Cdc5p is required for proper Swe1p regulation PMID: 15509790
9. Condensin/Cdc5-dependent removal of cohesin underscores the potential importance of crosstalk between chromosome structural components in chromosome morphogenesis and provides a mechanism to couple chromosome morphogenesis with other meiotic events. PMID: 16269332
10. findings show that Cdc5 controls the targeting and activation of Rho1 at the division site via Rho1 guanine nucleotide exchange factors to promote cytokinesis PMID: 16763112
11. Cdc5p is recruited to promoters of the cell-cycle-regulated CLB2 gene cluster, where it targets the Mcm1p-Fkh2p-Ndd1p transcription factor complex, through direct phosphorylation of the coactivator protein Ndd1p. PMID: 17122856
12. These observations suggest that concerted action of Cdc28 and Cdc5 on Nud1, Slk19, and Stu2 is important for proper spindle functions. PMID: 18178775
13. Data demonstrate that Cdc5 directly phosphorylates all three regulatory subunits of the condensin complex in vivo and that this causes a hyperactivation of condensin DNA supercoiling activity. PMID: 19481522
14. Cdc5 is a novel regulator of the SUMO pathway and suggest the outlines of a broader circuitry in which Ulp2 and Cdc5 act in a mutually antagonistic fashion to modulate maintenance and dissolution of cohesion at centromeres. PMID: 19823017

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KEGG: sce:YMR001C

STRING: 4932.YMR001C