cnp1 Antibody

1. Histone H3 removal during epigenetic centromere propagation.Ino80 promotes CENP-A chromatin assembly at the centromere. PMID: 28904333
2. We show that replication stresses, due to either hydroxyurea treatment or various forms of genetic lesions of the replication machinery, reduce the inheritance accuracy of CENP-A/Cnp1 nucleosome positioning within centromere. Mechanistically, we demonstrate that excessive formation of single-stranded DNA, a common molecular abnormality under these conditions, might have correlation with the reduction in fidelity of centro PMID: 28749973
3. Our results suggest that CENP-T particles occupy linkers between CENP-A nucleosomes and that classical regional centromeres differ from other centromeres by the absence of CENP-A nucleosome positioning PMID: 26275423
4. sequence-encoded features of centromeric DNA create an environment of pervasive low quality RNAPII transcription that is an important determinant of CENP-ACnp1 assembly. PMID: 25738810
5. The 19S proteasome (or its subcomplex) associates with centromeric chromatin and regulates distribution of CENP-A. PMID: 24710126
6. The CENP-A N-tail confers epigenetic stability to centromeres via the CENP-T branch of the constitutive centromere-associated network in fission yeast. PMID: 25619765
7. Data show that additional CENP-A(Cnp1) accumulates within and close to heterochromatic centromeric outer repeats, and over regions adjacent to rDNA and telomeres. PMID: 23936074
8. a small number of CENP-A/Cnp1 nucleosomes are found within the centromeric core and their positioning relative to underlying DNA varies among genetically homogenous cells PMID: 23661703
9. CENP-A(Cnp1) is deposited solely during the G2 phase of the cell cycle. PMID: 22870388
10. Top3 and Rqh1 normally limit the levels of CENP-A(Cnp1) in this region. This new role is independent of the established function of Top3 and Rqh1 in homologous recombination downstream of Rad51 PMID: 23516381
11. our analyses show that alterations in the process of chromatin assembly during transcription can destabilize H3 nucleosomes and thereby allow CENP-A(Cnp1) to assemble in its place. PMID: 23028377
12. Loss of the Mediator component Med20 impairs transcription silencing and heterochromatin formation. As a consequence, CENP-A Cnp1 is lost from the centromere, which disturbs kinetochore function and causes chromosome segregation defects. PMID: 22851695
13. The results suggest that the number of CENP-A molecules exceeds the number of kinetochore-microtubule (MT) attachment sites on each chromosome and that CENP-A is not the sole determinant of kinetochore assembly sites in Schizosaccharomyces pombe. PMID: 22084306
14. Identification of noncoding transcripts from within CENP-A chromatin at fission yeast centromeres. PMID: 21531710
15. CENP-A(Cnp1) chromatin assembly in fission yeast exhibits plasticity with respect to the underlying sequences and is sensitive to the levels of CENP-A(Cnp1) and other core histones PMID: 17677001
16. These observations imply that CENP-A is normally localized to centromeres in S phase in an Ams2-dependent manner and that the G2 pathway may salvage CENP-A assembly to promote genome stability. PMID: 18077559
17. Results suggest that one function of Sim3 is to act as an escort that hands off CENP-A(Cnp1) to chromatin assembly factors, allowing its incorporation into centromeric chromatin PMID: 18158900
18. findings show that the RNA interference (RNAi)-directed heterochromatin flanking the central kinetochore domain at fission yeast centromeres is required to promote CENP-A(Cnp1) and kinetochore assembly over the central domain PMID: 18174443

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KEGG: spo:SPBC1105.17

STRING: 4896.SPBC1105.17.1