cep-1 Antibody

1. Loss-of-function mutant of cep-1 decreased movement quiescence following UVC irradiation. PMID: 28754659
2. Results suggest that impaired p53/CEP-1 leads to an imbalance in the age-related energy metabolic alteration between mitochondrial oxidative phosphorylation and aerobic glycolysis and plays an important role in the extension of both intact and adaptive lifespans. PMID: 29114996
3. This work reveals an ancestral function for the p53 family in ensuring the fidelity of meiosis and establishes CEP-1 as a critical determinant of repair pathway choice. PMID: 27151662
4. Transcription factors CEP-1 and CEH-23 collaborate with AAK-2 to modulate longevity in Caenorhabditis elegans. PMID: 28560849
5. only 1mM DEM caused upregulation of egl-1, a gene controlled by a p53-orthologue, CEP-1.we suppressed GSH biosynthesis in worms by attenuating g-glutamylcysteine synthetase (gcs-1) expression through RNAi.gcs-1 knockdown commencing right after hatching impaired nematode stress resistance and rendered young adult worms prone to vulval ruptures during egg-laying. PMID: 28086197
6. Numerous ncRNAs are involved in CEP-1 transcriptional network and that these are especially enriched on the X chromosome in C. elegans. PMID: 24844773
7. Cross-talk between BEC-1 and CEP-1 protects the C. elegans genome. PMID: 24586407
8. We propose that CEP-1 responds to different mitochondrial ETC stress by mounting distinct compensatory responses accordingly to modulate animal physiology and longevity. PMID: 24586177
9. This review summarizes major advances in understanding of the TP53 family using C. elegans as a model organism. PMID: 23165352
10. In summary, the aging C. elegans uterus develops massive growths from endoreduplicating oocytes that are modulated by the CEP-1/p53 protein. PMID: 22562940
11. the C. elegans p53 homologue CEP-1 is partially required for activation of gst-4 when wdr-46 or other ribosome processing genes are silenced. PMID: 22240150
12. MAP kinase signaling controls CEP-1-dependent apoptosis by several different pathways that converge on CEP-1. PMID: 21901106
13. results show that APE1/EXO-3, p53/CEP-1, and thioredoxin affect each other and that these interactions determine aging as well as neuronal structure and function PMID: 20346071
14. reducing the expression of frataxin, the protein defective in patients with Friedreich's ataxia, triggers a complex stress response, and that the associated induction of the antioxidant glutathione-S-transferase is regulated by cep-1 PMID: 20172019
15. Genome-wide analysis of germ cell proliferation in C. elegans identifies vrk-1 as a key regulator of cep-1/p53. PMID: 20599896
16. Caenorhabditis elegans HIF-1 protects against DNA-damage-induced germ cell apoptosis by antagonizing the function of CEP-1, the homologue of the tumour suppressor p53 PMID: 20520707
17. This study reveals that the regulation of cep-1/p53 translation influences DNA damage-induced apoptosis and demonstrates the physiological importance of this mechanism. PMID: 15707894
18. Fatty acid synthase (FAS) gene, encoding for a key enzyme involved in the biogenesis of membrane lipids in rapidly proliferating cells, is a conserved target of the p53 family throughout the evolution. PMID: 16582625
19. Lag-3 has a role in regulating p53-mediated germ cell apoptotic response to DNA damage and expression of Ced-13 and Egl-1, downstream pro-apoptotic targets of the C. elegans p53 homolog Cep-1 PMID: 17317671
20. The solution structures of their the oligomerization domain (OD) of the p53 forms of the model organisms Caenorhabditis elegans and Drosophila are presented indicating that they both differ significantly from each other as well as from human p53. PMID: 17581633
21. RNA interference or genetic knockout of the p53 ortholog, cep-1, leads to increased life span, which is dependent upon functional daf-16. PMID: 17895432
22. Identification of a neddylation pathway and components of an SCF (Skp1/cullin/F-box) E3 ubiquitin ligase as negative regulators of cep-1-dependent germ cell apoptosis. PMID: 18340346
23. DNA damage induced apoptosis is an ancient function of the p53 family, and only a small number of genes are regulated by CEP-1. PMID: 18627611
24. These results indicate that the life span-extending effect of the cep-1 mutation is mediated by autophagy. PMID: 18728385
25. cep-1 also mediates both the developmental arrest and life shortening induced by severe mitochondrial stress. PMID: 19416129
26. The activation of innate immunity by inhibition of nucleolar proteins requires p53/CEP-1 and its transcriptional target SYM-1. PMID: 19763173

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KEGG: cel:CELE_F52B5.5

STRING: 6239.F52B5.5a.1

UniGene: Cel.18659