Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) chinmo Polyclonal antibody

Uniprot No.

Q9VQ30

Target Names

chinmo

Alternative Names

chinmo antibody; CG31666Zinc finger protein chinmo antibody; Protein chronologically inappropriate morphogenesis antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) chinmo protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Required for morphological differentiation of postmitotic neurons during postembryonic brain development. Ensures production of appropriate neuron subtypes within a lineage by preventing precocious generation of late neuronal types of that lineage. Acts as a downstream mediator of the transcriptional activator Stat92e and is required for the development of the eye-antennal disk which gives rise to the adult eye, antenna and head capsule, for transcriptional repression of the Notch receptor ligand Ser and for the self-renewal of cyst stem cells in the testis. In the adult testis, maintains the male identify of adult somatic cyst stem cells. Represses expression and alternative splicing of transformer pre-mRNA, resulting in the production of the male-specific isoform of transcription factor dsx which ensures male-specific transcription of target genes. Plays a role in actin nuclear localization through its involvement in repressing the expression of the kinase Cdi. This maintains the cofilin/actin-depolymerizing factor homolog tsr in its unphosphorylated state which is required for actin nuclear import.

Gene References into Functions

The BTB-zinc finger factor Chinmo acts upstream of ecdysone signaling to promote a neuronal fate switch. Indeed, Chinmo regulates the expression of the ecdysone receptor B1 isoform to mediate the production of gamma and alpha'beta' MB neurons PMID: 28966087
Transcriptional control of the sex determination hierarchy by Chinmo is critical for sex maintenance in sexually dimorphic tissues and is vital in the preservation of fertility. PMID: 29389999
Neuroepithelium differentiation in late larvae requires the transcriptional silencing of chinmo by ecdysone, the main steroid hormone, therefore allowing coordination of neural stem cell self-renewal with organismal growth. PMID: 29361557
we show that two co-transcribed Drosophila miRNAs, let-7 and miR-125, non-redundantly regulate a common target, the transcription factor Chronologically Inappropriate Morphogenesis (Chinmo). We first characterize novel adult phenotypes associated with loss of both let-7 and miR-125, which are derived from a common, polycistronic transcript that also encodes a third miRNA, miR-100. PMID: 27508495
chinmo is necessary and sufficient to promote a male identity in adult gonadal somatic cells; the sexual identity of somatic cells can be reprogrammed in the adult Drosophila ovary as well as in the testis. PMID: 26811385
ectopic expression of DsxM in the CySC lineage partially rescues the chinmo sex transformation phenotype, placing Chinmo upstream of DoublesexM PMID: 25453558
Let-7 and miR-125, cotranscribed from the let-7-complex (let-7-C) locus, regulate the transcription factor chinmo to control temporal cell fate in the mushroom body (MB) lineage. PMID: 22814608
Chinmo is a key effector of JAK/STAT signaling in a variety of developmental and pathological contexts PMID: 20412771
identified novel BTB-zinc finger protein, Chinmo, governing neuronal temporal identity during postembryonic brain development; results suggest temporal gradient of Chinmo helps specify distinct birth order-dependent cell fates in a neuronal lineage PMID: 17055440

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Subcellular Location

Nucleus.

Tissue Specificity

Broadly expressed in the developing larval central nervous system (at protein level). Expressed in the larval lymph gland and circulating hemocytes (at protein level). Expressed in all cell types of the adult testis stem cell niche but not detected in som

Database Links

KEGG: dme:Dmel_CG31666

UniGene: Dm.3973

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chinmo Antibody

Product Details

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Target Background