Coq7 Antibody

1. Clk1 plays a direct role in dopaminergic neuronal survival via regulating the autophagy-lysosome pathway that may contribute to the pathologic development of Parkinson disease. PMID: 29025968
2. Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis. PMID: 25339443
3. An enhanced immune response of Mclk1+/- mutant mice is associated with partial protection from fibrosis, cancer and the development of biomarkers of aging PMID: 23166727
4. These findings indicate that MCLK1 (also known as Coq7) regulates both coenzyme Q synthesis and distribution within mitochondrial membranes. PMID: 23045551
5. Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues PMID: 21447381
6. the partial resistance to I/R injury suggests that Mclk1(+/)(-) mutants have an enhanced recovery potential following age-dependant vascular accidents, which correlates well with their longer survival PMID: 20170652
7. CLK-1 protein has DNA binding activity specific to O(L) region of mitochondrial DNA. PMID: 11959146
8. clk-1 deficiency induces apoptosis associated with mitochondrial dysfunction in mouse embryos. PMID: 18343482
9. Mclk1 has a role in mitochondrial function, energy metabolism and the aging process PMID: 18635541
10. action of clioquinol on several age-dependent neurodegenerative diseases with distinct etiologies might result from a slowing down of the aging process through action of the drug on CLK-1. PMID: 18927074
11. Mclk1 heterozygosity does not necessarily protect against atherosclerosis. Moreover, in the presence of hyperlipidemia and chronic inflammation, Mclk1 heterozygosity is incapable of extending lifespan PMID: 19416523
12. Reduction in COQ7 levels gradually prevents the deterioration of mitochondrial function and associated increase of global oxidative stress that is normally observed in Sod2(+/-) mutants. PMID: 19478076

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KEGG: mmu:12850

STRING: 10090.ENSMUSP00000032887

UniGene: Mm.20634