ECO1 Antibody

1. The authors propose that the timing of Eco1 phosphorylation, and potentially that of other DDK substrates, is determined in part by sequestration of DDK at unfired replication origins during S phase. PMID: 28918948
2. Eco1 mediated acetylation regulates PCNA sliding on DNA in the presence of DNA damage, favoring homologous recombination linked to sister-chromatid cohesion. PMID: 27916662
3. Eco1p-mediated acetylation promotes establishment by abrogating the ability of Wpl1p to destabilize cohesin binding to chromosomes. PMID: 25378582
4. Data indicate that cell cycle protein Pds5 promotes acetylation of cohesin subunit Smc3 by acetyltransferase Eco1 during S phase. PMID: 23878248
5. the absence of Ctf4 and Chl1, but not of the other factors, causes a synthetic growth defect in cells lacking Eco1. PMID: 23334284
6. Eco1 degradation requires the sequential actions of Cdk1 and two additional kinases, Cdc7-Dbf4 and the GSK-3 homolog Mck1. PMID: 23314252
7. Acetylation of Mps3 by Eco1 is one of the few regulatory mechanisms known to control nuclear organization. PMID: 22593213
8. Data suggest that Cdk1-dependent phosphorylation of Eco1 is a key factor limiting establishment to S phase. PMID: 21549314
9. Eco1 promotes the reciprocal exchange of chromosome arms and maintenance of heterozygosity during mitosis. PMID: 20703090
10. During chromatid cohesion establishment, Eco1 is found at the DNA replication fork. PMID: 16962805
11. findings show that cohesion is generated by an Eco1-dependent but replication-independent mechanism in response to double-strand breaks in G(2)/M; Eco1 has 2 functions: a cohesive activity and a conserved acetyltransferase activity PMID: 17626885
12. This study identified a molecular target for the acetyltransferase Eco1 and revealed that Smc3 acetylation is a conserved mechanism in regulating sister chromatid cohesion. PMID: 18614053
13. findings show that Smc3 is acetylated in an Eco1-dependent manner during DNA replication to promote sister chromatid cohesion PMID: 18653893
14. study found that the head domain of the Smc3p subunit of cohesin is acetylated by the Eco1p acetyltransferase at two evolutionarily conserved residues, promoting the chromatin-bound cohesin to tether sister chromatids PMID: 18653894
15. Cdc28p CDK acts in sister chromatid cohesion parallel to Ctf7p reactions PMID: 18716324
16. required for the establishment of sister chromatid cohesion PMID: 18957238
17. Results provide a model where Eco1p and Wpl1p act as a simple positive and negative regulatory switch controlling cohesion generation. PMID: 19450529
18. The zinc finger may be a general enhancer of substrate recognition, thereby enhancing the ability of Eco1p to acetylate its substrates above a threshold needed to generate cohesion during DNA replication and repair. PMID: 19692582
19. Eco1 regulates proteins in the cohesin network through acetylation and plays an important role in the subnuclear organization of chromatin. PMID: 19948494

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KEGG: sce:YFR027W

STRING: 4932.YFR027W