EPA4A Antibody

Code CSB-PA835524XA01XBE
Product Type Polyclonal Antibody
Uniprot No. Q91845
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Xenopus laevis (African clawed frog) EPA4A protein
Raised in Rabbit
Species Reactivity Xenopus laevis (African clawed frog)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Ephrin type-A receptor 4-A (EC (Tyrosine-protein kinase receptor SEK-1) (xSEK-1) epha4-a sek1
Immunogen Species Xenopus laevis (African clawed frog)
Gene Names epha4-a
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections (By similarity).
Subcellular Location Cell membrane, Single-pass type I membrane protein, Early endosome
Protein Families Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
Database Links

KEGG: xla:779062

UniGene: Xl.57159

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