ERV1 Antibody

1. Chimeras between the N-terminal arm of ScErv1 and a variety of truncated LtErv constructs were able to rescue yeast cells that lack ScErv1. PMID: 29310075
2. Authors show that the fumarate reductase Osm1, which facilitates electron transfer from fumarate to succinate, fills this gap as a new electron acceptor. In addition to microsomes, Osm1 localizes to the mitochondrial intermembrane space and assembles with Erv1 in a complex. PMID: 28814504
3. Role of tryptophan residues of Erv1: Trp95 and Trp183 are important for its folding and oxidase function. PMID: 26221027
4. these results confirm that GSH is critical for cytosolic Fe-S protein biogenesis and iron regulation, whereas ruling out significant roles for Erv1 or Mia40 in these pathways. PMID: 26396185
5. Mia40 serves as an electron sink in the Mia40-Erv1 protein import pathway. PMID: 26085103
6. Taken together, we conclude that both shuttle cysteine residues are required for Erv1 function, and play complementary, but distinct, roles to ensure rapid turnover of active Erv1. PMID: 24625320
7. Mia40 in cooperation with Erv1 promotes the formation of two disulfide bonds in the substrate protein, ensuring the efficiency of oxidative folding in the intermembrane space of mitochondria. PMID: 22918950
8. These findings provide structural insights into electron transfer from Mia40 via the shuttle domain of one subunit of Erv1 to the CTD of another Erv1 subunit. PMID: 22910915
9. established that the N-terminal shuttle domain of Erv1 is necessary and sufficient for interaction with Mia40. PMID: 20367271
10. demonstrate that Erv1 dimerizes noncovalently and that the subunits of this homodimer cooperate in intersubunit electron exchange. PMID: 20188670
11. Sudies demonstrate that Mia40, Erv1, and oxygen are the minimal machinery for Tim13 oxidation. PMID: 19477928
12. We propose that Erv1 and Mia40 function as a disulfide relay system that catalyzes the import of proteins into the IMS by an oxidative folding mechanism. PMID: 15989955
13. Mia40 and Erv1, cooperate in the assembly pathway of small proteins of the mitochondrial intermembrane space PMID: 16181637
14. analysis of a disulfide relay system consisting of Mia40C and Erv1p PMID: 17959605
15. Erv1 utilizes diverse pathways for electron shuttling in the mitochondrial intermembrane space, including using cytochrome c and cytochrome c peroxidase PMID: 17972915
16. Oxidation driven by Mia40 and Erv1 determines vectorial transport of the precursors into the mitochondrial intermembrane space. PMID: 17978092
17. Erv1 promotes disulfide transfer to the precursor while both oxidase and precursor are associated with the disulfide carrier Mia40. PMID: 18852299
18. zinc is a powerful inhibitor of Erv1, an essential component of the import pathway used by the small Tim9,10 proteins PMID: 19117943
19. there is both intersubunit and intermolecular electron transfer at shuttle and active site disulfides s of mitochondrial sulfhydryl oxidase Erv1p PMID: 19679655

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KEGG: sce:YGR029W

STRING: 4932.YGR029W