FANCM Antibody

Code CSB-PA992586XA01DOA
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Product Details

Full Product Name
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) FANCM Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
FANCM antibody; At1g35530 antibody; F15O4.40DEAD-box ATP-dependent RNA helicase FANCM antibody; EC antibody; Fanconia anemia complementation group M-like protein antibody
Raised in
Species Reactivity
Arabidopsis thaliana
Recombinant Arabidopsis thaliana FANCM protein
Immunogen Species
Arabidopsis thaliana (Mouse-ear cress)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Involved in ordered homologous recombination (HR) events in somatic and meiotic cells. Involved in the suppression of spontaneous HR events in somatic cells. Has an opposite function to the DNA binding cofactor MHF1 which promotes spontaneous HR. Functions in replicative repair independently of MHF1 and in a parallel pathway to the endonuclease MUS81. Acts in the same pathway as the two DNA-binding cofactors MHF1 and MHF2 to restrain class II meiotic crossover (CO), and acts exclusively with MHF1 and MHF2 during meiosis to repair DNA interstrand cross-links (ICLs). This common pathway is in parallel to the pathway that involves the RECQ4A helicase. Seems to be involved in the stabilization of recombination intermediates. Involved in DNA double-strand break (DSB) repair during meiosis. Required for synthesis-dependent strand annealing (SDSA) and to a lesser extent for single-strand annealing (SSA). May process meiotic DSB repair intermediates, possibly D-loops, driving them toward noncrossover (NCO) resolution.
Gene References into Functions
  1. FIGL1 and FANCM represent barriers to crossover formation, one limiting strand invasion, the other disassembling D-loops to promote synthesis-dependent strand annealing, which when lifted, leads to a large increase of crossovers. PMID: 26161528
  2. At-FANCM is not only a safeguard for genome stability in somatic cells but is an important factor in the control of meiotic crossover formation. PMID: 22547783
  3. study identified the highly conserved FANCM helicase, as a major factor limiting meiotic crossover(CO)formation; FANCM is a key factor imposing an upper limit on the number of meiotic COs PMID: 22723424
Subcellular Location
Protein Families
DEAD box helicase family, DEAH subfamily, FANCM sub-subfamily
Database Links

KEGG: ath:AT1G35530

UniGene: At.39558

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