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| Code | CSB-PA008646XA01DIL |
| Product Type | Polyclonal Antibody |
| Uniprot No. | Q9I8X3 |
| Delivery | Make-to-order |
| Protocols | ELISA Protocol |
| Immunogen | Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) FGFR3 protein |
| Raised in | Rabbit |
| Species Reactivity | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Tested Applications | ELISA, WB (ensure identification of antigen) |
| Form | Liquid |
| Conjugate | Non-conjugated |
| Storage Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method | Protein A/G |
| Isotype | IgG |
| Clonality | Polyclonal |
| Alias | Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) fgfr3 |
| Immunogen Species | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Gene Names | fgfr3 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
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| Function | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity). |
| Subcellular Location | Cell membrane, Single-pass type I membrane protein |
| Protein Families | Protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily |
| Database Links |
UniGene: Dr.10434 |
| Pathway |
MAPK signaling pathway
PI3K-Akt signaling pathway Regulation of actin cytoskeleton Ras signaling pathway Signaling pathways regulating pluripotency of stem cells Rap1 signaling pathway Endocytosis |
fgfr3 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP008646DIL CSB-EP008646DIL CSB-BP008646DIL CSB-MP008646DIL |
Recombinant Danio rerio Fibroblast growth factor receptor 3(fgfr3),partial | Yeast E.coli Baculovirus Mammalian cell |
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