YFH1 Antibody

1. In the absence of Yfh1, Isu1 was found to exist in two forms, one mostly monomeric with limited tendency to dimerize, distinct structural features suggest that in physiological conditions the zinc-regulated abundance of monomeric vs. oligomeric Isu1 yields [Yfh1].[Isu1] complexes with different Isu1 configurations that afford unique functional properties for Fe-S cluster assembly and delivery. PMID: 28548666
2. YFH1 is spontaneously unfolded at low and high temperatures. PMID: 27802581
3. At an iron-to-protein ratio of 2, the initially monomeric Yfh1 is converted to a trimeric form in solution. PMID: 23344952
4. Frataxin (YFH1) deficiency in yeast cells leads to increased DNA base oxidation and requirement of Apn1 for DNA damage repair. PMID: 22706278
5. The authors observe that the high- and low-temperature denatured states of Yfh1 have similar but not identical residual secondary structures, different kinetics and compactness and a remarkably different degree of hydration. PMID: 22342930
6. in yeast, frataxin-deficiency interferes with mitochondrial dynamics, which might therefore be relevant for the pathophysiology of Friedreich ataxia. PMID: 22274609
7. Secondary inactivation of Aat1 contributes to the amplification of the respiratory defect observed in Deltayfh1 cells. PMID: 22010850
8. Metacaspase is associated with mitochondrial respiration, intracellular redox control and genomic stability. PMID: 22155640
9. The results revealed the types of oligomers present in solution and supported our earlier suggestions that the trimer is the main building block of yeast frataxin oligomers. PMID: 22051511
10. in Deltayfh1 cells, soluble phosphate is limiting, due to its co-precipitation with iron. PMID: 21189251
11. Deltayfh1 mutant exposed to oxidative stress has a drop in energy production and reducing power of the cells due to the damage of glycolytic enzymes and decrease in activity of enzymes involved in protein protection and regeneration. PMID: 20958246
12. Frataxin depletion in yeast triggers up-regulation of iron transport systems before affecting iron-sulfur enzyme activities PMID: 20956517
13. The ratio of soluble-to-insoluble iron did not change when the amount of Yfh1p was increased up to 4500 molecules per cell. The results do not support the hypothesis of Yfh1p being an iron storage protein in vivo. PMID: 20307653
14. YFH1 interacts with Isu1 through the conserved Trp-131. PMID: 19884169
15. Changing the conserved beta-sheet residues Asn122-Lys123-Gln124 had no effect on Yfh1 stability and plasticity. PMID: 20001966
16. The semi-conserved pocket of negative charge within the 'acidic ridge' region significantly increase the YFH1 structural flexibility. PMID: 20141512
17. oligomerization, and thus oligomerization-induced iron storage, is not a critical function of Yfh1 PMID: 15472712
18. defective heme formation in mutants, with a markedly more severe defect in the DeltaDeltaDelta than in the individual Deltamrs3/4 or Deltayfh1 mutants PMID: 15767258
19. Consequently, we suggest a direct participation of the respiratory chain in the pathogenesis of the Friedreich ataxia, which we propose to be considered as an OXPHOS disease. PMID: 15961414
20. mutations that specifically impair the ferroxidation or mineralization activity of yeast frataxin, which are necessary for iron detoxification but do not affect the iron chaperone function of the protein PMID: 16371422
21. analysis of YFH1 shows that manganese-superoxide dismutase deficiency is a consequence of iron overload PMID: 16510442
22. characterization of the binding properties and metal-site structure of ferrous iron bound to monomeric frataxin PMID: 16784228
23. These results support the idea that the surface of the beta-sheet, adjacent to the acidic, iron binding ridge, is important for interaction of Yfh1 with the Fe-S cluster scaffold and point to a critical role for frataxin in Fe-S cluster biogenesis. PMID: 18319250
24. particle image reconstructions show the iron core of frataxin PMID: 18393441
25. Glutathione is a valuable indicator of the redox status of frataxin-deficient cells in a yeast model of Friedreich's ataxia. PMID: 18562474
26. Yfh1 assembly responds to dynamic changes in mitochondrial iron uptake or stress exposure in a highly controlled fashion PMID: 18784075
27. Major frataxin-related phenotypes ([Fe-S] cluster assembly and heme synthesis) can be split in vivo, suggesting that frataxin has independent roles in both processes, and that the optimal conditions for these independent roles are different. PMID: 19460301
28. frataxin drives assembly of core machinery for mitochondrial iron-sulfur cluster synthesis PMID: 19491103

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KEGG: sce:YDL120W

STRING: 4932.YDL120W