FUN30 Antibody

1. Budding yeast Fun30 and human SMARCAD1 are cell cycle-regulated by interaction with the DNA double strand break-localized scaffold protein Dpb11/TOPBP1, respectively. In yeast, this protein assembly additionally comprises the 9-1-1 damage sensor, is involved in localizing Fun30 to damaged chromatin, and thus is required for efficient long-range resection of DNA double strand breaks. PMID: 28063255
2. Fun30 acts to down regulate Rad9-dependent DNA damage checkpoint triggered by CPT or MMS, but does not affect Rad9-independent intra-S phase replication checkpoint induced by MMS or HU. It supports the notion that Fun30 contributes to cellular response to DSBs by preventing excessive DNA damage checkpoint activation in addition to its role in facilitating DNA end resection. PMID: 28089177
3. Cdk1 and multiple cyclins become highly enriched at DSBs and that the recruitment of Cdk1 and cyclins Clb2 and Clb5 ensures optimal Fun30 phosphorylation and checkpoint activation. PMID: 26801641
4. These results define a role for Fun30 in the regulation of transcription and indicate that Fun30 remodels chromatin at the 5' end of genes by sliding promoter-proximal nucleosomes. PMID: 23779104
5. Fun30, a poorly characterized member of the Swi2/Snf2 family of chromatin remodelers, plays a role in end processing by facilitating the Exo1 and Sgs1-Dna2 resection pathways. PMID: 23147792
6. Fun30 is required to allow the adaptation of DNA damage checkpoint-arrested cells with an unrepaired double-strand break to resume cell cycle progression. PMID: 23007155
7. our findings indicate a direct role of Fun30 in centromere chromatin by promoting correct chromatin architecture. PMID: 23028372
8. the yeast nucleosome-remodelling enzyme Fun30 is a factor promoting double-strand break end resection; data suggest that Fun30 helps to overcome the inhibitory effect of Rad9 on DNA resection PMID: 22960743
9. findings unveil an evolutionarily conserved role for the Fun30 and SMARCAD1 chromatin remodellers in controlling end resection, homologous recombination and genome stability in the context of chromatin PMID: 22960744
10. the Snf2 homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme PMID: 20075079
11. Fun30 is directly involved in silencing by regulating the chromatin structure within or around silent loci. PMID: 19956593

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KEGG: sce:YAL019W

STRING: 4932.YAL019W