GAL4 Antibody

1. To facilitate application of the KZip(+) technology, we have developed a versatile set of LexAop-KZip(+) fly lines that can be used directly with the large number of LexA driver lines with known expression patterns. KZip(+) significantly sharpens the precision of neuronal genetic control available in Drosophila and may be extended to other organisms where Split GAL4-like systems are used. PMID: 28363977
2. Report drosophila line in which the expression of yeast GAL4 is up-regulated in response to ingestion of silver nanoparticles PMID: 23827194
3. Gal4 binds to GAL gene UASGAL (upstream activation sequence in GAL gene promoter) sites as a dimer via its N-terminal domain and activates transcription via a C-terminal transcription activation domain (AD). PMID: 23858060
4. Double-transgenic mice in a GAL4/WNT1 system exhibit increased locomotor activity, decreased social interaction, and impaired short-term spatial memory and nesting behavior. PMID: 23134367
5. Gal80 binds to the activation domain of Gal4 and prevents it from activating transcription. PMID: 22479149
6. These data demonstrate that Gal80 is a powerful addition to the genetic techniques available to map and manipulate neural circuits in zebrafish. PMID: 21905164
7. Data show that the DE-Gal4 line is a useful tool with which to manipulate gene expression in half of Drosophila developing eye. PMID: 19882738
8. A chimeric transactivator in which the Gal4 DNA-binding domain is fused to the activation domain of viral protein VP16 (GAL4-VP16) tightly associates with yeast chromatin and reorganizes nucleosome arrays by an ATP-independent mechanism. PMID: 15766286
9. Gal4 ubiquitylation and destruction are required for initiation-competent transcription complexes to transition to fully mature elongating complexes capable of appropriate mRNA processing. PMID: 15797387
10. identified polypeptides in close physical proximity to Gal4 during transcription activation PMID: 16199885
11. Review provides an updated account of Gal4 function, including data from new technologies that have been recently applied to the study of the GAL network. PMID: 16670683
12. Under non-inducing conditions, the complex is dynamic, but on induction the Gal4-promoter complexes 'lock in' and exhibit long half-lives; inhibition of proteasome-mediated proteolysis had little or no effect on Gal4-mediated gene expression PMID: 16929306
13. The chimeric transcription factor Gal4-VP16 can enhance SWI/SNF histone octamer transfer activity, resulting in targeted histone eviction from a nucleosome probe. PMID: 17235287
14. Increased gal4 dosage correlated with accumulation of insoluble GAL4, suggesting that the cascade of events leading to apoptosis might be triggered by protein deposits of either GAL4 or protein intermediates PMID: 17313569
15. An engineered yeast Gal4 transcription activator construct illustrates a method that is applicable to functional studies of neural circuits in transgenic zebrafish. PMID: 18202183
16. This study validates the physiological importance of Gal4 monoubiquitylation and clarifies its major role as that of protecting the activator from being destabilized by the proteasomal ATPases. PMID: 18326036
17. A report on the structure of a complete Gal4 dimer bound to DNA and additional biochemical studies to address the molecular basis for Gal4 dimerization in DNA binding. PMID: 18611375
18. In the presence of galactose, Gal4p-YFP remained in the nucleus. PMID: 18952899
19. These results, using the Gal4BD-Spo11 fusion protein, demonstrate that Spo11 itself has sequence preference and contributes to the choice of DNA double-strand break positions. PMID: 19380488
20. Gal4p can be crosslinked to Gal80p with bis(sulphosuccinimidyl) suberate. PMID: 11964151

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KEGG: sce:YPL248C

STRING: 4932.YPL248C