His2Av Antibody

1. H2Av or H3S10 phosphorylation by JIL-1 is not required for chromatin decondensation or transcriptional elongation in Drosophila. PMID: 28807902
2. The nucleosome positioning sequence (NPS) patterns from H2A.Z nucleosomes differ from the NPS patterns from H2A nucleosomes. The purine-purine/pyrimidine-pyrimidine pattern of H2A.Z nucleosomes has major peaks shifted by 10 bp deviated from the H2A nucleosome pattern. The H2A and H2A.Z nucleosomes have different sequence preferences. PMID: 27992255
3. the H2AZ-like rather than the H2AX-like function of H2AV is primarily required for normal hematopoiesis. PMID: 28242611
4. The Drosophila histone variant H2A.V works in concert with HP1 to promote kinetochore-driven microtubule formation. PMID: 25591068
5. nucleosomes present significant, context-specific barriers to RNAPII in vivo that can be tuned by the incorporation of H2A.Z PMID: 24606920
6. chromatin loosening and associated initiation of gene expression is activated by phosphorylation of H2Av in a nucleosome positioned in promoter regions of PARP-1-dependent genes PMID: 24508391
7. Unlike other organisms that employ several H2A variants for different functions, the parsimonious fruit fly Drosophila melanogaster gets along with just a single H2A variant, H2A.V. Remarkably, H2A.V unites within one molecule features and functions of two different mammalian H2A variants, H2A.Z and H2A.X. [Review] PMID: 23553272
8. H2A.Z nucleosome occupancy has no effect on sequence variability of Drosophila genome PMID: 23472174
9. PARP1 is targeted to chromatin by association with the histone H2A variant (H2Av). PMID: 21444826
10. in the absence of H2A.Z, checkpoint-defective telomeres adopt alternative structures, which are permissive for the loading of the capping machinery at Drosophila telomeres. PMID: 18845840

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KEGG: dme:Dmel_CG5499

STRING: 7227.FBpp0084434

UniGene: Dm.2346