hdeA Antibody

1. HdeA binds its substrates heterogeneously, and the "amphiphilic" model for HdeA-substrate interaction is discussed. PMID: 29016106
2. HdeB activation is coupled to its intrinsic dynamics instead of structural changes, and therefore its functional mechanism is apparently different from HdeA. PMID: 26593705
3. these results provide insight into the process by which HdeA is primed to unfold and carry out its chaperone duties below pH 3.0 PMID: 24375557
4. The small periplasmic chaperone HdeA is directly activated by partial unfolding in a low ph environment. PMID: 23487787
5. The authors conclude that E. coli O157:H7 strains have evolved acid survival strategies independent of the HdeA/B chaperones and are more acid resistant than nonpathogenic K-12. PMID: 22179243
6. HdeA exposes hydrophobic surfaces that appear to be involved in the binding of denatured substrate proteins at extremely low pH values PMID: 15911614
7. HdeA and HdeB not only help to maintain proteins in a soluble state during acid treatment, as previously reported, but also assist, both in vitro and in vivo, in the solubilization at neutral pH of mixed protein-chaperone aggregates formed at acidic pH PMID: 18359765
8. the partially unfolded character of active HdeA allows the chaperone to adopt different conformations as required for the recognition and high-affinity binding of different substrate proteins. PMID: 19321422

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KEGG: ecj:JW3478

STRING: 316385.ECDH10B_3686