ISW1 Antibody

1. single mutations in genes ISW1, ISW2, and CHD1 weakly affect repair and mutagenic processes in yeast cells. PMID: 29372964
2. Study identifies the yeast ISW1 chromatin remodeling complex as an unanticipated mRNP nuclear export surveillance factor that retains export-incompetent transcripts near their transcription site. This tethering activity of ISW1 requires chromatin binding and is independent of nucleosome sliding activity or changes in RNA polymerase II processivity. PMID: 27863241
3. The chromatin remodelers RSC and ISW1 display functional and chromatin-based promoter antagonism. PMID: 25821983
4. nucleosome mobilizing activity of Isw1a, Isw1b and Isw2 complexes could be significantly influenced by neighboring nucleosomes PMID: 24530316
5. The nuclease digestion data suggest that Isw1a can also promote ATP-dependent distortion of nucleosome structure, although less efficiently than the Isw1b complex. PMID: 24050724
6. nuclear localization signal is located at the end of the ISW1 C-terminus. PMID: 23121014
7. We find that remodelers( Isw1, Isw2, and Chd1 ) occupancy at NDRs and gene bodies is associated with nucleosome turnover and transcriptional elongation rate PMID: 23468649
8. Distinct ISWI-family members translocate nucleosomes with a similar stepping pattern maintained by the catalytic subunit of the enzyme. Nucleosome remodeling begins with a 7 bp step of DNA translocation followed by 3 bp subsequent steps toward the exit side of nucleosomes. PMID: 23374341
9. Deletion of ISW1 and CHD1 causes widespread intragenic transcription. PMID: 22922743
10. Histone H3 lysine 36 methylation promoted the chromatin interaction of the Isw1b chromatin-remodeling complex in Saccharomyces cerevisiae. PMID: 22751925
11. fndings show that the combined action of Isw1 and Chd1 nucleosome-spacing enzymes are responsible for directing the positioning of the majority of nucleosomes within the Saccharomyces cerevisiae genome PMID: 21940898
12. ISWI and Chd1 remodelling factors are not only involved in transcription-related chromatin remodelling, but also are required to maintain a specific chromatin configuration across the yeast genome. PMID: 16468993
13. ISWI and Chd1 chromatin remodeling complexes have roles in nucleosome repositioning PMID: 16606615
14. Data support a model in which Isw1 acts independently of the previously characterized Isw1a and Isw1b complexes to maintain a heterochromatin-like structure at the rDNA that is required for gene silencing. PMID: 17561109
15. Data show that, although defective in nucleosome remodeling, Isw1 lacking the SANT domain is able to repress transcription initiation at the MET16 promoter. PMID: 19273607

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KEGG: sce:YBR245C

STRING: 4932.YBR245C