JMJ25 Antibody

Code CSB-PA106412XA01DOA
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Product Details

Full Product Name Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) JMJ25 Polyclonal antibody
Uniprot No. Q9SSE9
Target Names JMJ25
Alternative Names JMJ25 antibody; IBM1 antibody; At3g07610 antibody; MLP3.6 antibody; Lysine-specific demethylase JMJ25 antibody; EC 1.14.11.- antibody; Jumonji domain-containing protein 25 antibody; Lysine-specific histone demethylase JMJ25 antibody; Protein INCREASE IN BONSAI METHYLATION 1 antibody; Protein JUMONJI 25 antibody
Raised in Rabbit
Species Reactivity Arabidopsis thaliana
Immunogen Recombinant Arabidopsis thaliana JMJ25 protein
Immunogen Species Arabidopsis thaliana (Mouse-ear cress)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

(From Uniprot)
Histone demethylase that demethylates 'Lys-9' (H3K9me) of histone H3 with a specific activity for H3K9me2 and H3K9me1. No activity on H3K9me3, H3K4me3/2/1, H3K27me3/2/1 and H3K36me3/2/1. Involved in the control of several developmental processes by protecting genes from silencing. Demethylates H3K9me2 in the promoter regions of RDR2 and DCL3 and mediates the repression of ectopic non-CpG methylation at RDR2, DCL3 and APC13 loci. Protects also a large number of transcribed genes from non-CpG methylation. May regulate gene expression via a pathway involving indirect silencing of gene expression through small RNA-directed DNA methylation (RdDM)-directed repression.
Gene References into Functions
  1. Results show that ibm1 mutation causes a very severe growth phenotype with a much reduced plant size and affects the expression of a large number of genes. PMID: 28400174
  2. The authors show that both ibm1 and edm2 mutants display defects in production of stomatal lineage cells, which is linked to DNA hypermethylation of the ERECTA family genes, including ER, ERL1 and ERL2 Stomatal phenotypes and DNA methylation levels of ER genes in ibm1 and edm2 mutants are restored by mutations in the genes encoding the histone methyltransferase KYP and DNA methyltransferase CMT3. PMID: 27697902
  3. our results suggest a function for SG1 in the maintenance of genome integrity by regulating IBM1. PMID: 24404182
  4. EDM2 promotes IBM1 distal polyadenylation and regulates genome DNA methylation PMID: 24248388
  5. The results suggest that IBM1 regulates gene expression through two distinct pathways: direct association to protect genes from silencing by preventing the coupling of histone and DNA methylation, and indirect silencing of gene expression through RNA-directed DNA methylation-directed repression. PMID: 22772985
  6. It was shown that the expression of the H3K9 demethylase IBM1 requires DNA methylation. Surprisingly, the regulatory methylated region is contained in an unusually large intron that is conserved in IBM1 orthologues. PMID: 22580822
  7. Study identified a jmjC-domain gene, IBM1 (increase in bonsai methylation 1); ibm1 mutations induced a variety of developmental phenotypes, which depend on methylation of histone H3 at lysine 9 in addition to the ectopic cytosine methylation. [IBM1] PMID: 18218897
  8. Results suggest that IBM1 prevents the CHG methylation in Arabidopsis genes, but not in transposons. PMID: 19262562

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Subcellular Location Nucleus.
Database Links

KEGG: ath:AT3G07610

STRING: 3702.AT3G07610.3

UniGene: At.18334

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