jmjd-3.1 Antibody

Code CSB-PA592222XA01CXY
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Product Details

Full Product Name Rabbit anti-Caenorhabditis elegans jmjd-3.1 Polyclonal antibody
Uniprot No. Q95QK3
Target Names jmjd-3.1
Alternative Names jmjd-3.1 antibody; F18E9.5 antibody; Lysine-specific demethylase jmjd-3.1 antibody; EC 1.14.11.- antibody; JmjC domain-containing protein 3.1 antibody
Raised in Rabbit
Species Reactivity Caenorhabditis elegans
Immunogen Recombinant Caenorhabditis elegans jmjd-3.1 protein
Immunogen Species Caenorhabditis elegans
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

Function
(From Uniprot)
Histone demethylase that specifically demethylates trimethylated 'Lys-27' of histone H3, a mark associated with transcriptional repression, thereby playing a central role in the histone code. Involved in the transcriptional regulation of the heat shock response, unfolded protein response and possibly other stress response target genes. Required for gonad development and organization. Required for the robust transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development. Acts cell-autonomously in Y-to-PDA transdifferentiation, which depends on the demethylase activity and on recognition of the H3 tail. Cooperates with set-2 and unc-3 to ensure robust Y-to-PDA transdifferentiation. Promotes mitochondrial stress-induced longevity. Involved in lifespan regulation.
Subcellular Location Nucleus.
Protein Families UTX family
Tissue Specificity Mainly expressed in head and tail.
Database Links

KEGG: cel:CELE_F18E9.5

STRING: 6239.F18E9.5b.2

UniGene: Cel.17165

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