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| Code | CSB-PA819878XA01CXY |
| Size | Enquire |
| Have Questions? | Leave a Message or Start an on-line Chat |
| Full Product Name | Rabbit anti-Caenorhabditis elegans jnk-1 Polyclonal antibody |
| Uniprot No. | Q8WQG9 |
| Target Names | jnk-1 |
| Alternative Names | jnk-1 antibody; B0478.1Stress-activated protein kinase jnk-1 antibody; EC 2.7.11.24 antibody |
| Raised in | Rabbit |
| Species Reactivity | Caenorhabditis elegans |
| Immunogen | Recombinant Caenorhabditis elegans jnk-1 protein |
| Immunogen Species | Caenorhabditis elegans |
| Conjugate | Non-conjugated |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification Method | Protein A/G |
| Concentration | It differs from different batches. Please contact us to confirm it. |
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Form | Liquid |
| Tested Applications | ELISA, WB (ensure identification of antigen) |
| Protocols | ELISA Protocol |
| Troubleshooting and FAQs | Antibody FAQs |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Value-added Deliverables | ① 200ug * antigen (positive control); ② 1ml * Pre-immune serum (negative control); |
| Quality Guarantee | ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection; ② ELISA titer can be guaranteed 1: 64,000; ③ WB validation with antigen can be guaranteed positive; |
| Lead Time | Made-to-order (14-16 weeks) |
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| Function (From Uniprot) |
Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity. By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses. Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16. Independently of jkk-1, may regulate some mechanosensory responses, such as response to touch. Independently of jkk-1 and downstream of mek-1, plays a role in resistance to heavy metals, such as Cu(2+) or Cd(2+). Regulates germline cell apoptosis in response to heavy metals such as Cu(2+) and arsenite. Required for dopaminergic CEP neuron degeneration in response to Mn(2+). Required for normal sleep bout quantity and arousal thresholds during the transition from the last larval stage to adulthood in well-fed animals. Downstream of jkk-1 but independently of mek-1, positively regulates lifespan. |
| Gene References into Functions |
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| Subcellular Location | Cytoplasm. Perikaryon. Cell projection, axon. |
| Protein Families | Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily |
| Tissue Specificity | Expressed in most neurons, including nerve ring, head ganglions, dorsal and ventral nerve cords and tail ganglions. The Thr-276/Tyr-278 phosphorylated form is present in the nerve ring upon heat exposure. |
| Database Links |
KEGG: cel:CELE_B0478.1 STRING: 6239.B0478.1a UniGene: Cel.18197 |
