Name: jmjd-1.2 Antibody
Brand: CUSABIO
SKU: CSB-PA861968XA01CXY

Product Details

Full Product Name	Rabbit anti-Caenorhabditis elegans jmjd-1.2 Polyclonal antibody
Uniprot No.	Q9GYI0
Target Names	jmjd-1.2
Alternative Names	jmjd-1.2 antibody; F29B9.2Lysine-specific demethylase 7 homolog antibody; ceKDM7A antibody; EC 1.14.11.- antibody; JmjC domain-containing protein 1.2 antibody; PHD finger protein 8 homolog antibody; PHF8 homolog antibody
Raised in	Rabbit
Species Reactivity	Caenorhabditis elegans
Immunogen	Recombinant Caenorhabditis elegans jmjd-1.2 protein
Immunogen Species	Caenorhabditis elegans
Conjugate	Non-conjugated
Clonality	Polyclonal
Isotype	IgG
Purification Method	Protein A/G
Concentration	It differs from different batches. Please contact us to confirm it.
Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form	Liquid
Tested Applications	ELISA, WB (ensure identification of antigen)
Protocols	ELISA Protocol
Troubleshooting and FAQs	Antibody FAQs
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables	① 200ug * antigen (positive control); ② 1ml * Pre-immune serum (negative control);
Quality Guarantee	① Antibody purity can be guaranteed above 90% by SDS-PAGE detection; ② ELISA titer can be guaranteed 1: 64,000; ③ WB validation with antigen can be guaranteed positive;
Lead Time	Made-to-order (14-16 weeks)

Target Background

Function (From Uniprot)	Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. Promotes mitochondrial stress-induced longevity.
Gene References into Functions	jmjd-1.2 has a role in axon guidance that might be relevant for the onset of X-linked mental retardation PMID: 28126843 Study demonstrates that both jmjd-1.2 and jmjd-3.1 are necessary and sufficient for activation of the UPRmt in C. elegans and identifies jmjd-1.2 and jmjd-3.1 as positive regulators of a longevity response that genetically requires UPRmt signaling. PMID: 27133168
Subcellular Location	Nucleus.
Protein Families	JHDM1 histone demethylase family, JHDM1D subfamily
Tissue Specificity	Mainly expressed in neurons. Also weakly expressed in some muscle, intestinal and hypodermal cells.
Database Links	STRING: 6239.F29B9.2a UniGene: Cel.17181

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jmjd-1.2 Antibody

Code	CSB-PA861968XA01CXY
Size	Enquire
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