jmjd-1.2 Antibody

Code CSB-PA861968XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans jmjd-1.2 Polyclonal antibody
Uniprot No.
Target Names
jmjd-1.2
Alternative Names
jmjd-1.2 antibody; F29B9.2Lysine-specific demethylase 7 homolog antibody; ceKDM7A antibody; EC 1.14.11.- antibody; JmjC domain-containing protein 1.2 antibody; PHD finger protein 8 homolog antibody; PHF8 homolog antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans jmjd-1.2 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. Promotes mitochondrial stress-induced longevity.
Gene References into Functions
  1. jmjd-1.2 has a role in axon guidance that might be relevant for the onset of X-linked mental retardation PMID: 28126843
  2. Study demonstrates that both jmjd-1.2 and jmjd-3.1 are necessary and sufficient for activation of the UPRmt in C. elegans and identifies jmjd-1.2 and jmjd-3.1 as positive regulators of a longevity response that genetically requires UPRmt signaling. PMID: 27133168
Subcellular Location
Nucleus.
Protein Families
JHDM1 histone demethylase family, JHDM1D subfamily
Tissue Specificity
Mainly expressed in neurons. Also weakly expressed in some muscle, intestinal and hypodermal cells.
Database Links

STRING: 6239.F29B9.2a

UniGene: Cel.17181

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