jmjd-1.2 Antibody

Code CSB-PA861968XA01CXY
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Product Details

Full Product Name Rabbit anti-Caenorhabditis elegans jmjd-1.2 Polyclonal antibody
Uniprot No. Q9GYI0
Target Names jmjd-1.2
Alternative Names jmjd-1.2 antibody; F29B9.2Lysine-specific demethylase 7 homolog antibody; ceKDM7A antibody; EC 1.14.11.- antibody; JmjC domain-containing protein 1.2 antibody; PHD finger protein 8 homolog antibody; PHF8 homolog antibody
Raised in Rabbit
Species Reactivity Caenorhabditis elegans
Immunogen Recombinant Caenorhabditis elegans jmjd-1.2 protein
Immunogen Species Caenorhabditis elegans
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

(From Uniprot)
Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. Promotes mitochondrial stress-induced longevity.
Gene References into Functions
  1. jmjd-1.2 has a role in axon guidance that might be relevant for the onset of X-linked mental retardation PMID: 28126843
  2. Study demonstrates that both jmjd-1.2 and jmjd-3.1 are necessary and sufficient for activation of the UPRmt in C. elegans and identifies jmjd-1.2 and jmjd-3.1 as positive regulators of a longevity response that genetically requires UPRmt signaling. PMID: 27133168
Subcellular Location Nucleus.
Protein Families JHDM1 histone demethylase family, JHDM1D subfamily
Tissue Specificity Mainly expressed in neurons. Also weakly expressed in some muscle, intestinal and hypodermal cells.
Database Links

STRING: 6239.F29B9.2a

UniGene: Cel.17181

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