Trim71 Antibody

1. LIN41 interacts with p53, controls its abundance by ubiquitination and antagonizes p53-dependent pro-apoptotic and pro-differentiation responses. In vivo, lack of LIN41 is associated with upregulation of Grhl3 and widespread caspase-3 activation, 2 downstream effectors of p53 with essential roles in neural tube closure. PMID: 28430184
2. suggest that Trim71 keeps priming steps of differentiation in check, which do not pre-require a loss of the pluripotency network in ES cells PMID: 26057209
3. mLin41 acts as a temporal regulator to promote neural progenitor cell maintenance, not via the regulation of AGO2 stability, but through FGF signaling. PMID: 22508726
4. The transcripts of mlin-41 and the protein level in mouse adult tissues and embryos from 9.5 to 13 days were detected by RT-PCR and western blot. PMID: 20824311
5. Lin-41 is genetically and biochemically downstream of both the Shh and Fgf signaling pathways and is expressed in three phases over developmental time and most notably is associated with the developing autopod. PMID: 16245339
6. lin-41 is temporally regulated by miRNAs in order to direct key developmental events such as limb formation. PMID: 16247770
7. Strong loss of function Mlin41 gene-trap mutants demonstrated a striking neural tube closure defect during development, and embryonic lethality. PMID: 19098426
8. demonstrate the presence of mLin41 protein in several stem cell niches, including the embryonic ectoderm, epidermis and male germ line. PMID: 19898466

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KEGG: mmu:636931

STRING: 10090.ENSMUSP00000107447

UniGene: Mm.17857