Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) HSP70-4 Polyclonal antibody

Uniprot No.

Q9LHA8

Target Names

HSP70-4

Alternative Names

HSP70-4 antibody; HSC70-4 antibody; HSP70 antibody; MED37_2 antibody; MED37C antibody; At3g12580 antibody; T16H11.7 antibody; T2E22.11Heat shock 70 kDa protein 4 antibody; Heat shock cognate 70 kDa protein 4 antibody; Heat shock cognate protein 70-4 antibody; AtHsc70-4 antibody; Heat shock protein 70-4 antibody; AtHsp70-4 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana HSP70-4 protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions (Probable). ATP-dependent molecular chaperone that assists folding of unfolded or misfolded proteins under stress conditions. Mediates plastid precursor degradation to prevent cytosolic precursor accumulation, together with the E3 ubiquitin-protein ligase CHIP. Recognizes specific sequence motifs in transit peptides and thereby led to precursor degradation through the ubiquitin-proteasome system. Plays a critical role in embryogenesis.; In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions.

Gene References into Functions

ability of multiple unrelated Hsp70-binding elements to support protein import verified that the majority of TPs utilize an N-terminal Hsp70-binding domain during translocation and expand the mechanistic view of the import process PMID: 25645915
temperature regulated expression of AtHSP70-4 may be mediated by cell cycle transcription factors and participate in plant acclimations to non-stress temperature changes PMID: 25451247
This work describes a detailed quantitative interaction study between the novel plastidial chaperone receptor OEP61 and isoforms of the chaperone types Hsp70 and Hsp90 using the optical method of total internal reflection ellipsometry. PMID: 21767504
Chloroplasts have two chaperone systems facilitating protein translocation into the stroma: the cpHsc70 system and the Hsp93/Tic40 system. PMID: 20484004
A working hypothesis is that Hsp70 has a defense-promoting activity(s) that HopI1 or high temperature can subvert. PMID: 20615948
The MAPK-EGR-1-HSP70 pathway regulates the cigarette smoke-induced inflammatory process. PMID: 17494953

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Subcellular Location

Cytoplasm, cytosol. Nucleus.

Protein Families

Heat shock protein 70 (TC 1.A.33) family, DnaK subfamily

Tissue Specificity

Expressed in cotyledons, leaves, stems, vascular bundles, roots, stigmas and anthers.

Database Links

KEGG: ath:AT3G12580

STRING: 3702.AT3G12580.1

UniGene: At.47608

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HSP70-4 Antibody

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