mec-4 Antibody

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Code	CSB-PA326156XA01CXY
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Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans mec-4 Polyclonal antibody

Uniprot No.

P24612

Target Names

mec-4

Alternative Names

mec-4 antibody; mec-13 antibody; T01C8.7Degenerin mec-4 antibody; Mechanosensory abnormality protein 4 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans mec-4 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Subunit of an amiloride-sensitive cation channel (degenerin channel complex) permeable for sodium, potassium, lithium and N-methylglucamine, and required for mechanosensory transduction (touch sensitivity). Negatively regulates the turning step of male mating behavior.

Gene References into Functions

Ubiquitination of MEC-4 reduces the amount of MEC-4 protein in the processes of ALM neurons and, consequently, the mechanoreceptor current. PMID: 25653375
bz2 mutation encodes substitution A745T, which is situated in the intracellular C-terminal domain of MEC-4. We show that this substitution renders both MEC-4 and MEC-4(d) activity strongly temperature sensitive PMID: 16239217
The d position is part of a key region in the channel functionally and structurally, possibly representing the beginning of a pore-forming domain. PMID: 17261841
MEC-4/MEC-10 DEG/ENaC or its partners MEC-6, MEC-7, and MEC-9 blocked DAF-16::GFP nuclear accumulation induced by hypergravity but did not affect DAF-16 response to other stresses PMID: 17720915
MEC-4 is distributed essentially evenly with MEC-2 around the circumference of touch receptor neurites that serve as gating tethers critical for channel activation by mechano-electrical transduction. PMID: 18094248

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Subcellular Location

Membrane; Multi-pass membrane protein. Cell projection, axon.

Protein Families

Amiloride-sensitive sodium channel (TC 1.A.6) family

Tissue Specificity

Expressed in AVM, ALM, PVM and PLM touch neurons.

Database Links

KEGG: cel:CELE_T01C8.7

STRING: 6239.T01C8.7.2

UniGene: Cel.634

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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mec-4 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background