MPH1 Antibody

1. Mutator phenotype of MPH1 overexpression suggests a novel gain-of-function mechanism. DEAH-box function was required for hypermutation, mutagenesis by MPH1 overexpression was independent of translesion synthesis, but was suppressed by overexpression of RAD27. PMID: 27585847
2. Mph1regulates the REC-mediated choice between gene conversion and break-induced replication (BIR). Double deletion of Sgs1 and Mph1 abolishes the REC-mediated lag observed during the repair of large gaps and BIR substrates. PMID: 27075725
3. Mte1 functions with Mph1 and the associated MHF complex in replication fork repair PMID: 26966246
4. Mph1 and Mte1 interdependently colocalize at DNA damage-induced foci and dysfunctional telomeres, and MTE1 deletion results in elongated telomeres PMID: 26966248
5. Data support the hypothesis that Mph1 is the main helicase responsible for template switching during break-induced replication. PMID: 24496010
6. Mph1 does not affect the overall efficiency of gap repair, and its loss alters the CO-NCO by promoting synthesis-dependent-strand-annealing at the expense of HJ-containing intermediates. PMID: 23516370
7. Mph1 is a double-edge sword at the telomere, it prevents NHEJ, but promotes senescence in cells with dysfunctional telomeres by increasing the levels of ssDNA PMID: 22848695
8. Characterization of Mph1 helicase activity with a variety of DNA substrates, focusing on its action on junction structures containing three or four DNA strands. PMID: 22090425
9. These biochemical results not only provide validation for a role of Mph1 in the repair of damaged replication forks, but they also offer mechanistic insights as to its ability to efficiently disrupt the D-loop intermediate. PMID: 21880555
10. Mph1 has an additional function in recombination besides its previously described ability to disrupt D-loops; Mph1 promotes D-loop formation. PMID: 20951099
11. This study describes a synthetic growth defect of an mph1 deletion if combined with an srs2 deletion that can result-depending on the genetic background-in synthetic lethality. PMID: 19918932
12. the MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicase PMID: 15634678
13. Mph1p promotes gross chromosomal rearrangement formation by partially suppressing homologous recombination, likely through its interaction with replication protein A. PMID: 18591428
14. a new role of Mph1 in promoting the noncrossover repair of DNA double-strand breaks PMID: 19136626
15. These findings suggest that Mph1 plays an important, although not essential, role in processing of Okazaki fragments by facilitating the formation of ligatable nicks. PMID: 19181670

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KEGG: sce:YIR002C

STRING: 4932.YIR002C