msl-2 Antibody

1. the only male-specific protein within the Male-Specific Lethal complex; in addition to regulating the X chromosome, targets autosomal genes involved in patterning and morphogenesis PMID: 30194291
2. HOW is required for SXL to retain msl2 transcripts in the nucleus PMID: 23788626
3. Solution structure of MSL2 CXC domain reveals an unusual Zn3Cys9 cluster and similarity to pre-SET domains of histone lysine methyltransferases. PMID: 23029009
4. MSL2 can fulfill its role as the central regulator of the faithful biogenesis and functionality of the dosage compensation(DC) machinery. PMID: 23084834
5. A model is proposed in which a non-chromatin-associated partial or complete MSL-complex titrates newly transcribed msl2 mRNA and thus regulates the amount of available MSL complex by feedback. PMID: 21551218
6. Reporter gene assays and localization of GFP-fusion proteins confirm the important contribution of the CXC domain of MSL2 for Dosage Compensation Complex targeting in vivo. PMID: 20139418
7. suggest a model in which male-specific lethal (MSL) proteins assemble into active complexes by binding nascent roX transcripts PMID: 12446910
8. spreads from roX genes on the Drosophila X chromosome. PMID: 12782651
9. dSLX binds to the 3'UTR of msl-2 mRNA and activates the translational repressor domain, thereby enabling it to recruit co-repressors in a specific fashion. PMID: 14532129
10. MSL2 controls male-specific roX expression in the absence of any other MSL protein. PMID: 15126401
11. Here, we uncover the mechanism by which SXL achieves tight control of msl-2 translation initiation. This failsafe mechanism thus forms the molecular basis of a critical step in dosage compensation. PMID: 16122421
12. the association of MSL2 with the X chromosome is exceptionally stable, essentially excluding dynamic redistribution of the dosage compensation complex during interphase PMID: 16179989
13. X chromosome binding of MSL1 requires a conserved leucine zipper-like motif that binds to MSL2. PMID: 16199870
14. Our results reveal a novel functional role for UNR as a translational repressor and indicate that UNR is a key component of a "fail-safe" dosage compensation regulatory system that prevents toxic MSL-2 synthesis in female cells PMID: 16452508
15. Results suggest that the MSL complex (including MSL-1, -2, and -3) uses high-affinity sites to initially recognize the X chromosome and then associates with many of its targets through sequence-independent features of transcribed genes. PMID: 17936709
16. Incorporation of the roX RNAs into the MSL complex alters the binding specificity of the chromatin-binding module formed by the amino-terminal domains of MSL1 and MSL2. PMID: 18086881
17. in metafemales with ectopically expressed MSL2, the autosomal expression is returned to a more normal level. PMID: 19556782
18. Efficient msl-2 mRNA silencing via the 3' UTR requires both a poly(A) tail and PABP function, indicating that UNR directly interacts with PABP. PMID: 19941818

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KEGG: dme:Dmel_CG3241

STRING: 7227.FBpp0077259

UniGene: Dm.14311