Msx2 Antibody

1. The MSX2 gene is expressed in ameloblasts. The knockdown of MSX2 can inhibit the expression of enamel matrix proteins and the enamel mineralization. PMID: 29773104
2. Data support a crucial role for Msx2 in the osteochondrogenic differentiation of vascular smooth muscle cells from insulin-resistant ob/ob mice. PMID: 28829997
3. Msx2 may act indirectly on dentinogenesis by controlling osteoclast activity and the signaling network related to eruption, supporting and further extending the concept that Msx2 controls formation of mineralized tissues by inhibition of the Wnt/beta-catenin pathway; Sost in dentin and Dkk1 in bone, as previously demonstrated. PMID: 27524798
4. Msx2 is intensely expressed in the OEE and supra-OEE of the lateral side of the epithelium in mice. PMID: 26042621
5. Msx1 and Msx2 are direct transcriptional targets of Lhx2 PMID: 25460335
6. Msx2 supports vascular mineralization by directing the osteogenic programming of aortic progenitors in diabetic arteriosclerosis. PMID: 25056439
7. Msx2 plays an important role in craniofacial morphogenesis and growth because almost all craniofacial structures were affected in the Msx2(-/-) mice including both intramembranous and endochondral bones, the cochlear apparatus, and the teeth. PMID: 24387797
8. Msx2 (-/-) Rank(Tg) mice had significant improvement in the molar phenotype, while incisor epithelium defects were exacerbated in the enamel area, with formation of massive osteolytic tumors PMID: 24278237
9. HR regulates expression of genes in the MSX2 regulatory pathway, which explains abnormal hair follicle formation in Hr(Hp)/Hr(Hp) skin. PMID: 23702391
10. Ambn plays a crucial role in the regulation of cranial bone growth and suture closure via Msx 2 suppression and proliferation inhibition. PMID: 23593111
11. Data show that Dlx5 and Msx2 play a critical role in controlling cranial neural tube morphogenesis by regulating cell adhesion via the ephrinA5 and EphA7 pathway. PMID: 23425387
12. in AER cells and, at later stages, in the limb mesoderm the regulation of by Dlx5 and Dlx6 occurs also cell autonomously PMID: 23382810
13. MSX2 preserves endothelial phenotype in aortic endothelial cells. PMID: 23685555
14. These results provide the first direct genetic evidence of the involvement of MSX2 in Peters anomaly and the distinct function of MSX2 in regulating the growth and development of lens vesicles. PMID: 22503753
15. activation of RAGE not only inhibits myocardin-dependent SMC gene expression, but also induces osteogenic differentiation of vascular SMC through Notch/Msx2 induction PMID: 21512281
16. Msx2 and Foxn1 regulate differentiation of the keratogenous zone, proliferation of distal nail matrix cells, and organization of the nail bed. PMID: 21387539
17. Dlx5, Msx2, and Runx2 enhancers exhibit a dual requirement for TCF/LEF1 and Smad binding element (SBE) sites that mediate synexpression of the three genes during osteoblast differentiation. PMID: 20878775
18. Notch1 intracellular domain.RBPJk complex enhances the BMP2-induced Msx2 gene expression by cooperating with Smad1 and suggest that Notch signaling makes vascular SMC responsive to BMP2 and promotes vascular calcification. PMID: 21471203
19. the results of this study indicate that TNF-alpha enhances the Wnt/beta-catenin signaling pathway by inducing Msx2 expression, which in turn suppresses adipocytic differentiation. PMID: 21514273
20. Msx2 and Runx2 likely function together to induce PC-1 gene expression in osteoblastic cells and FGF signaling stimulates Msx2 transcriptional activity through the Frs2 mediated MAPK signaling pathway PMID: 20803545
21. Specific enamel and periodontal phenotypes of Msx2 mutant mice constitute the first case report of structural and signaling defects associated with enamel protein overexpression in a postnatal context. PMID: 20934968
22. The absence of myocardial defects in the Msx2 knock-out cannot be attributed to a redundant action of Msx1 in the myocardium. PMID: 20225205
23. MSx2 mediates the inhibitory action of TNFalpha on osteoblast differentiation. PMID: 20440096
24. Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3.( PMID: 20484411
25. Inactivation of Msx1 and Msx2 in neural crest reveals an unexpected role in suppressing heterotopic bone formation in the head PMID: 20398647
26. These data suggest that the gene expressions of ntrk2 and msx2 were significantly suppressed in KIT mutant mouse embryo and neonate and that these genes are likely to regulate interstitial cells of Cajal development. PMID: 20460112
27. These results indicate Msx2 possesses dual regulatory functions in controlling cell cycle progression of retinal retinal ganglion cells (RPCs) and timing of RGCs differentiation. PMID: 20394734
28. MSX2 expression in the apical ectoderm ridge is regulated by an MSX2 and Dlx5 binding site PMID: 11798166
29. Data show that the combinatorial defects in hair cycling and differentiation, together with concealed skin domains, account for the cyclic alopecia phenotype in Msx2-deficient mice. PMID: 12466204
30. Cross-talk between Msx/Dlx homeobox genes and vitamin D during tooth mineralization. Msx2 overexpression and vitamin D addition inhibited osteocalcin expression in immortalized MO6-G3 odontoblasts. PMID: 12489206
31. receptor tyrosine kinase-like orphan receptor 2(Ror2) sequesters Dlxin-1 in membranous compartments, thereby affecting the transcriptional function of homeobox, msh-like 2(msx2) PMID: 12754255
32. Msx2 regulates osteogenic versus adipogenic differentiation of aortic myofibroblasts PMID: 12925529
33. graded expression is regulated by Smad4 and beta-catenin interaction with lymphoid-enhancing factor PMID: 14551209
34. Data suggest that Msx2 and Twist cooperate in the control of the differentiation and proliferation of skeletogenic mesenchyme. PMID: 14597577
35. Results suggest that Msx2 plays a central role in preventing ligaments and tendons from mineralizing, in part by suppressing Runx2/Osf2 transcriptional activity. PMID: 15060165
36. Msx2 acts as a master gene regulating smooth muscle (SM) differentiation in at least a subset of SMCs. PMID: 15155529
37. Msx2 homeodomain protein has a role in promoting myogenic differentiation via MAGE-D1 and Necdin PMID: 15272023
38. Dlx5 transactivates ALP expression, directly by binding to its cognate response element and/or indirectly by stimulating Runx2 expression, and Msx2 counteracts the direct transactivation of Dlx5 PMID: 15383550
39. Results describe gene regulation by Dlx3 in relation to that of Msx2 and Dlx5 during osteoblast differentiation. PMID: 15456894
40. BMP-responsive sequence highly conserved in Msx2 promoters from mammalian orders, not found in others, but is in Drosophila PMID: 15459107
41. during amelogenesis Msx2 is required for the expression of the extracellular matrix gene Laminin 5 alpha 3, which is known to play an essential role during ameloblast differentiation. PMID: 15499554
42. Dlx5 specifically transactivates the Runx2 P1 promoter, and its action on the P1 promoter is antagonized by Msx2 PMID: 16115867
43. Critical role for Msx2 in counteracting the effect of Diethylstilbestrol on Female reproductive tract patterning. PMID: 16513791
44. The three homeodomain proteins MSX2, DLX3, and DLX5 provide a key series of molecular switches that regulate expression of Runx2 throughout bone formation. PMID: 17060321
45. Co-immunoprecipitation analyses identified that the carboxyl-terminal domain (residues 218-359) of C/EBPalpha is required for the C/EBPalpha-Msx2 protein-protein interactions. PMID: 17210130
46. Progesterone, acting through its receptor, induces Msx2 to enhance ductal branching in the mammary gland. PMID: 17546050
47. Msx2 has a critical and functionally redundant role in regulating calvaria morphogenesis of the cranial neural crest lineage within the frontal bone primordium. PMID: 17693062
48. TGF-beta/Msx2 signaling cascade is critical for development of the caudal region of the skull PMID: 17727833
49. study provides a detailed analysis of the phenotype resulting from the Msx2 null mutation and identifies the impact of Msx1 and Msx2 on post-natal oral bone growth PMID: 17878071
50. Msx2Tg increased osteogenic differentiation via mechanisms inhibited by Dkk1 PMID: 18487199

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KEGG: mmu:17702

STRING: 10090.ENSMUSP00000021922

UniGene: Mm.1763