PAT1 Antibody

1. the studies presented here identify a set of residues at the very C-terminal end of Lsm1 to be functionally important and suggest that these residues support the function of the Lsm1-7-Pat1 complex by facilitating RNA binding either directly or indirectly PMID: 27434131
2. Pat1 affects the structure of CEN chromatin and protects Cse4 from Psh1-mediated ubiquitination for faithful chromosome segregation. PMID: 25833709
3. The mRNA fate modulators Dhh1 and Pat1 redundantly stimulate mRNA decay, but both factors are required for poly(A) tail-independent translation repression by tethered TNRC6A. PMID: 25657010
4. Pat1 C-terminal domain displays two conserved regions involved in decapping factor recruitment PMID: 24830408
5. The middle domain of Pat1 is essential for the interaction of Pat1 with the Lsm1-7 complex in vivo. PMID: 25035297
6. The Pat1 C-terminal domain interacting with the C-terminal helix of Lsm2 and the N-terminal helix of Lsm3 extended RNA-binding surface provides a possible molecular explanation for the preferred binding of the Lsm1-7-Pat1 complex to longer RNAs. PMID: 24247251
7. our data have uncovered a novel role for Pat1 in maintaining the structural integrity of centromeric chromatin to facilitate faithful chromosome segregation and proper kinetochore function. PMID: 23893485
8. These data provide the first evidence that Dhh1 is required for Pat1 nuclear relocation after UV stress. PMID: 23847025
9. The results suggest a model for how Dhh1-containing messenger ribonucleoprotein particles might be remodeled upon Pat1 and Edc3 binding. PMID: 23851565
10. LSm1, Pat1, and Dhh1 control the RNA3/RNA1 ratio of Flock House virus RNAs. PMID: 23536653
11. Pull-down experiments reveal that the intracellular binding partners of Pat1 change as cells undergo the diauxic growth shift. PMID: 21712243
12. inhibition of translation initiation and induction of P-body formation by overproduction of Dhh1 or Pat1 cause tRNA nuclear accumulation in nutrient-replete conditions PMID: 21398402
13. The overexpression of Pat1p causes translational repression, P body formation, and arrests cell growth. PMID: 16179257
14. The Lsm1p-7p-Pat1p complex protects mRNAs by binding at/near the 3'end and distinguishes between oligoadenyLated and polyadenylated RNA. PMID: 17513695
15. These results indicate that Pat1 is an RNA binding protein and a multidomain protein that functions at multiple stages in the process of translation repression and mRNA decapping PMID: 18086885
16. These results underscore the importance of Lsm1p-7p-Pat1p complex-mRNA interaction for mRNA decay in vivo and imply that the oligo(A) tail mediated enhancement of such interaction is crucial in that process. PMID: 18719247

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KEGG: sce:YCR077C

STRING: 4932.YCR077C