RAD30 Antibody

1. Profiles of base-substitutions created by Polzeta & Poleta of Saccharomyces cerevisiae were analyzed. Poleta created deletions at the lesion in more than 50% of the TLS products, but the formation of the deletions was suppressed by the presence of Polzeta. Polzeta & Poleta cooperatively facilitated the TLS reaction over an abasic site in vitro, suggesting that these two polymerases can cooperate in efficient and high f... PMID: 28946034
2. This study provides further understanding of the mutation mechanism of alkylated lesion for yeast DNA polymerase eta. PMID: 26976707
3. These data indicate that under certain conditions, pol eta can compete with the cell's replicases and gain access to undamaged genomic DNA. PMID: 26340535
4. The stability of Pol eta, but not its mRNA level, is cell cycle stage dependent. The half-life of the polymerase is more than fourfold shorter in G1-arrested cells than in those at G2/M. PMID: 25766643
5. This study provides further understanding in the mutation mechanism of abasic sites for yeast DNA polymerase eta PMID: 26203649
6. study found both Pol zeta and Pol eta are necessary for efficient gap repair and that each functions independently of the other; these polymerases may be involved either in initiation of DNA synthesis from the invading end or in a gap-filling process that is required to complete recombination PMID: 24210827
7. For base pair substitutions, polymerase eta appears to be related in function and epistatic to DNA polymerase zeta which, however, plays the opposite role in the nucleus. PMID: 23313845
8. our results suggest that other elements in the RAD30 C-terminal region may contribute to the ubiquitin binding in conjunction with the ubiquitin binding zinc finger domain PMID: 21483899
9. DNA polymerase eta, which is encoded by the RAD30 gene, is solely responsible for the bypass of T-T dimers but is rarely involved in the bypass of T-T (6-4) photoadducts or abasic sites. PMID: 15520252
10. RAD30 (polymerase eta) replicates through 8-oxoG without any barriers introduced by the presence of the lesion. PMID: 15743815
11. These results are the first indication of a role for controlled proteasomal degradation in modulating cellular level of translesion DNA polymerase (Rad30)in eukaryotes. PMID: 17198712
12. A ubiquitin-binding domain provides enhanced affinity for the ubiquitylated form of PCNA and is essential for in vivo function of the polymerase eta. PMID: 17251197
13. Although pol eta could accommodate large bulges and continue synthesis without obstruction, bulge structures in the template, but not in the primer, caused termination of the T7 DNA replication complex PMID: 17303570
14. Data suggest that mutations in the C2H2 motif have no perceptible effect on UV sensitivity or UV mutagenesis, whereas a mutation of the D570 residue adversely affects DNA polymerase eta function. PMID: 17709386
15. Although in yeast a stable Rev1-Pol eta complex can be formed, this complex formation involves the polymerase-associated domain of Rev1 and not the Rev1 C terminus as in humans. PMID: 17875922
16. Evolutionary conservation of efficient T[CPD]T bypass by HsPoleta and AtPoleta may reflect a high degree of exposure of human skin and plants to solar UV-B radiation PMID: 18366182

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KEGG: sce:YDR419W

STRING: 4932.YDR419W