SIT4 Antibody

1. suggest that Sit4p-mediated dephosphorylation of Atp2p-T124/T317 downregulates Atp2p alongside with ATP synthase and mitochondrial function PMID: 29719209
2. Phytoceramide accumulation and Sit4-dependent signaling mediate the mitochondrial dysfunction and shortened lifespan in the yeast model of Niemann-Pick type C1, in part through modulation of the Pkh1-Sch9 pathway. PMID: 28988886
3. This pathway is functionally relevant to TORC1 signaling since the stress sensitivity of a nonessential TORC1 mutant (tco89Delta) to hydroxyurea and arsenic can be reversed by combining tco89Delta with either hst3Delta, hst4Delta, or sit4Delta Surprisingly, while hst3Delta or hst4Delta rescues the sensitivity tco89Delta has to low concentrations of the TORC1 inhibitor rapamycin, sit4Delta fails to do so PMID: 27343235
4. The results suggest that the phosphorylated Hxk2 functions downstream of Sit4 in the control of cell cycle, mitochondrial function, oxidative stress resistance and chronological lifespan. PMID: 27163342
5. Results show that Sit4p and its mammalian orthologue, PP6, regulate traffic from the ER to the Golgi complex which is consistent with its role in coat recycling. PMID: 23864707
6. Sit4p is essential for rapid translation of HXT1. PMID: 22882630
7. Data show that the Reg1-Glc7 protein phosphatase 1 and Sit4 type 2A-like phosphatase are largely responsible for dephosphorylation of Thr-210 of Snf1(1-309). PMID: 22589305
8. Data show that Tec1 protein stability is under control of the nutrient-sensitive target of rapamycin complex 1 (TORC1) signaling pathway via the Tip41-Tap42-Sit4 branch. PMID: 21840851
9. Epistasis experiments support a model in which Rts3 and Sds23/24 act in parallel to negatively regulate Sit4, while Hse1 confers caffeine resistance via a separate pathway. PMID: 21360731
10. Roles of two protein phosphatases, Reg1-Glc7 and Sit4, and glycogen synthesis in regulation of SNF1 protein kinase. PMID: 21464305
11. These data uncover a new regulatory pathway that connects multidrug resistance to Sit4p function. PMID: 20608983
12. Sit4 forms a complex with Rrd1 (Ptpa1) that mediates repair of oxidative DNA damage caused by 4-nitroquinoline-1-oxide and Ultraviolet A. PMID: 15150670
13. Snf1 protein kinase and Sit4 protein phosphatase have opposing functions in regulating TATA-binding protein association with the Saccharomyces cerevisiae INO1 promoter PMID: 15716495
14. Sit4 activity masked nitrogen source-dependent changes in Gln3-Myc(13) phosphorylation which were clearly visible when SIT4 was deleted. PMID: 17015442
15. Sit4p regulates the transcriptional repressor activity of Mig1pregulated by a post-transcriptional pathway. PMID: 18022394
16. sit4-110 has pronounced actin polarization defects under both absence and presence of dipyridyl disulfide. PMID: 18357452
17. Tap42 functions in the same positive direction as Sit4, Pph21 and Pph22 in Ty1 transcriptional silencing, providing support to the idea that Tap42 may play a positive role in phosphatase activity in response to TORC1 signalling PMID: 18949822
18. PP2A-dependent Gln3 dephosphorylation parallels conditions where Gln3 is mostly nuclear, while Sit4-dependent and Rap-induced dephosphorylation parallels those where Gln3 is mostly cytoplasmic PMID: 19015262

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KEGG: sce:YDL047W

STRING: 4932.YDL047W