RGT2 Antibody

Code CSB-PA618591XA01SVG
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Product Details

Full Product Name Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) RGT2 Polyclonal antibody
Uniprot No. Q12300
Target Names RGT2
Alternative Names RGT2 antibody; YDL138W antibody; D2160 antibody; High glucose sensor RGT2 antibody; Low-affinity glucose receptor RGT2 antibody; Low-affinity transporter-like sensor RGT2 antibody; Restores glucose transport protein 2 antibody
Raised in Rabbit
Species Reactivity Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) RGT2 protein
Immunogen Species Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

(From Uniprot)
Low-affinity high glucose sensor that is part of the sensor/receptor-repressor (SSR) glucose-signaling pathway, which detects extracellular glucose and induces expression of glucose transporters that bring glucose into the cell. The transporter-like sensor generates an intracellular signal in the presence of high levels of glucose to promote high glucose-induced expression of HXT1. Binding of glucose to the RGT2 transmembrane domain activates a downstream signaling cascade, leading to phosphorylation of the RGT1 corepressors MTH1 and STD1, targeting them for SCF(Grr1)-dependent ubiquitination and degradation. Depletion of the corepressors robs RGT1 of its ability to repress expression of HXT genes, leading to accumulation of glucose transporters in the plasma membrane. Even though RGT2 is similar to glucose transporters, it appears to be unable to transport glucose.
Gene References into Functions
  1. RGT2 constitutive mutations alter evolutionarily-conserved amino acids in the transmembrane spanning regions of Rgt2. They cause Rgt2 to adopt inward-facing or occluded conformations that generate the glucose signal. PMID: 29954842
  2. RGT2-1 promotes ubiquitination and subsequent degradation of Mth1 and Std1 regardless of the presence of glucose. PMID: 17586499
Subcellular Location Cell membrane; Multi-pass membrane protein.
Protein Families Major facilitator superfamily, Sugar transporter (TC 2.A.1.1) family
Database Links

KEGG: sce:YDL138W

STRING: 4932.YDL138W

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