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| Code | CSB-PA618591XA01SVG |
| Size | Enquire |
| Have Questions? | Leave a Message or Start an on-line Chat |
| Full Product Name | Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) RGT2 Polyclonal antibody |
| Uniprot No. | Q12300 |
| Target Names | RGT2 |
| Alternative Names | RGT2 antibody; YDL138W antibody; D2160 antibody; High glucose sensor RGT2 antibody; Low-affinity glucose receptor RGT2 antibody; Low-affinity transporter-like sensor RGT2 antibody; Restores glucose transport protein 2 antibody |
| Raised in | Rabbit |
| Species Reactivity | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Immunogen | Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) RGT2 protein |
| Immunogen Species | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Conjugate | Non-conjugated |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification Method | Protein A/G |
| Concentration | It differs from different batches. Please contact us to confirm it. |
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Form | Liquid |
| Tested Applications | ELISA, WB (ensure identification of antigen) |
| Protocols | ELISA Protocol |
| Troubleshooting and FAQs | Antibody FAQs |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Value-added Deliverables | ① 200ug * antigen (positive control); ② 1ml * Pre-immune serum (negative control); |
| Quality Guarantee | ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection; ② ELISA titer can be guaranteed 1: 64,000; ③ WB validation with antigen can be guaranteed positive; |
| Lead Time | Made-to-order (14-16 weeks) |
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| Function (From Uniprot) |
Low-affinity high glucose sensor that is part of the sensor/receptor-repressor (SSR) glucose-signaling pathway, which detects extracellular glucose and induces expression of glucose transporters that bring glucose into the cell. The transporter-like sensor generates an intracellular signal in the presence of high levels of glucose to promote high glucose-induced expression of HXT1. Binding of glucose to the RGT2 transmembrane domain activates a downstream signaling cascade, leading to phosphorylation of the RGT1 corepressors MTH1 and STD1, targeting them for SCF(Grr1)-dependent ubiquitination and degradation. Depletion of the corepressors robs RGT1 of its ability to repress expression of HXT genes, leading to accumulation of glucose transporters in the plasma membrane. Even though RGT2 is similar to glucose transporters, it appears to be unable to transport glucose. |
| Gene References into Functions |
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| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Protein Families | Major facilitator superfamily, Sugar transporter (TC 2.A.1.1) family |
| Database Links |
KEGG: sce:YDL138W STRING: 4932.YDL138W |
