RNT1 Antibody

1. The functional cycle of eukaryotic Rnt1p includes five consecutive steps of double-stranded RNA processing. PMID: 28111020
2. the data suggest that Rnt1p reactivity is triggered by malleable RNA degradation signals that permit dynamic response to changes in growth conditions PMID: 25680180
3. The double stranded RNA binding domain and N-terminal domains of Rnt1p function as two rulers that measure the distance between the tetraloop and the cleavage site. PMID: 24703949
4. The Rnt1p double-stranded RNA binding domain has an extended hydrophobic core comprising helix alpha1, the alpha1-beta1 loop, and helix alpha3. PMID: 23201338
5. RNase III (Rnt1p) is required for progression of the cell cycle and nuclear division. PMID: 15090619
6. A new alpha-helical extension promotes RNA binding by the dsRBD of RNT1. PMID: 15192703
7. Rnt1p selectively inhibits gene expression in baker's yeast by directly cleaving a stem-loop structure within the mRNA coding sequence. PMID: 15668170
8. A new role of yeast RNase III in the processing of intron-encoded snoRNAs that permits independent regulation of the host mRNA and its associated snoRNA was shown. PMID: 15798187
9. The solution structure of the dsRNA-binding domain (dsRBD) of Rnt1p bound to a cognate RNA substrate revealed the structural basis for binding of the conserved tetraloop motif by alpha-helix 1 of the dsRBD. PMID: 15987808
10. Rnt1p physically interacts with RNA polymerase I (RNAPI) and its deletion decreases the transcription of the rRNA gene and increases the number of rRNA genes with an open chromatin structure PMID: 17991894
11. The results indicate that Rnt1p uses a network of nucleotide interactions to identify its substrate and support two distinct modes of binding. PMID: 18646867
12. A fail-safe transcription termination mechanism is mediated by Rnt1 cleavage of the nascent transcript in S. cerevisiae. PMID: 19818712
13. Results support a model for transcription termination in which cotranscriptional cleavage by Rnt1p provides access for exoribonucleases in the absence of polyadenylation signals. PMID: 19818713

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KEGG: sce:YMR239C

STRING: 4932.YMR239C