RSP5 Antibody

1. These data raised the possibility that Rsp5 enhances the function of Ena1/2/5 specifically in response to sodium acetate through an unknown mechanism other than ubiquitination of Rim8 and activation of Hog1-mediated signaling. PMID: 29106511
2. Authors present the molecular features in the methionine permease Mup1 that are required for Art1-Rsp5-mediated ubiquitination and endocytosis. PMID: 27798240
3. Rsp5 may be phosphorylated by PKA at position T761 and that this regulation is important for its localization and function. PMID: 26548973
4. subjecting yeast to proteotoxic stress, particularly thermal stress, triggers arresting related trafficking adaptor-Rsp5-mediated clearance of misfolded plasma membrane proteins. PMID: 23599894
5. Our findings suggest that stress-induced quality control is a common process requiring Rsp5p for plasma membrane proteins in yeast. PMID: 25001409
6. Rsp5 and its mammalian homologue Nedd4 are important E3 ligases responsible for the increased ubiquitylation induced by heat stress. PMID: 25344756
7. SUMOylation regulates the homologous to E6-AP carboxyl terminus (HECT) ubiquitin ligase Rsp5p. PMID: 23443663
8. In one highly sensitive cluster on the surface of ubiquitin, almost every amino acid substitution caused growth defects. PMID: 23376099
9. our results show that Rsp5 ligase plays a role in regulating retrograde Golgi-to-ER trafficking. PMID: 22761830
10. Rsp5 together with Lsb1, Lsb2 and Sla1 regulate the level of Las17, an important activator of actin polymerization. PMID: 22000681
11. Yeast ubiquitin ligase Rsp5 contains nuclear localization and export signals PMID: 21868125
12. suggest that functional Rsp5p is required to maintain the integrity of cytoplasmic ribosomes under rich nutrient conditions PMID: 21665996
13. Results support a model in which the N-lobe-binding site acts to localize and orient the distal end of the ubiquitin chain to promote conjugation of the next ubiquitin molecule. PMID: 21399621
14. Bsd2 is a three-transmembrane domains protein with a PPXY motif that binds the HECT domain ubiquitin ligase Rsp5 PMID: 14988731
15. Rsp5p plays a novel and key role in intracellular trafficking, and extend the currently very short list of substrates ubiquitylated in vivo by several different ubiquitin ligases acting cooperatively PMID: 15086787
16. Rsp5 is important for recovery from heat-induced protein synthesis arrest PMID: 15527788
17. Counteraction of PUT4 downregulation by npi1 mutation that affects cellular ubiquitination function is reported. PMID: 15973048
18. results suggest that enhanced phosphatidylinositol synthesis may account for PIS1 suppression of rsp5 defects PMID: 16363994
19. Sequential assembly of first a Bsd2/Rsp5 complex, then a Tre1/Bsd2/Rsp5 complex followed by a rearrangement of PY-WW interactions is required for the ubiquitination of Smf1. PMID: 17429078
20. identification of numerous known and novel ubiquitinated substrates of this E3 ligase PMID: 17551511
21. Rsp5 ubiquitin ligase is required for vacuolar targeting and degradation of high-affinity copper transporter Ctr1p fused to green fluorescent protein, following the endocytic downregulation pathway requiring delivery to the vacuole. PMID: 17645432
22. A combination of yeast proteome chip assays, genetic screening, and in vitro/in vivo biochemical analyses was used to identify and characterize eight novel in vivo substrates of the ubiquitinating enzyme Rsp5. PMID: 17951556
23. turnover of the low affinity P i transporters is initiated by Rsp5-mediated ubiquitination followed by internalization and degradation by the endocytic pathway. PMID: 18165238
24. lysine residues 983 and 985 contained within the carboxy-terminal domain of Mga2p120 are Rsp5p-directed Ub-conjugation sites PMID: 19061897
25. Rsp5p plays an important role in the post-transcriptional fate of mRNA under nutrient starvation. PMID: 19180642
26. Point mutations that disrupt ubiquitin binding also result in temperature-sensitive growth defects in yeast, indicating that the Rsp5 ubiquitin-binding site is important for Rsp5 function in vivo PMID: 19252184
27. inhibits tombavirus replication via p92 replication protein and replicase PMID: 19759160

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KEGG: sce:YER125W

STRING: 4932.YER125W