SCC2 Antibody

1. Nipbl seems to have also additional roles, for instance as transcription factor.This chapter summarizes our current knowledge on kollerin function and the recent studies on the genomic localization of Scc2, highlighting and critically discussing controversial data. PMID: 27797076
2. The role of Scc2 in cohesin loading PMID: 27280786
3. Authors conclude that normal Scc2 function requires modulation of its phosphorylation state and suggest that scc2 phosphomimetic mutants cause an increased incidence of abortive cohesin deposition events that result in compromised cohesin complex integrity and Mcd1 turnover. PMID: 26354421
4. Scc2 normally promotes a gene expression program that supports translational fidelity. . translational dysfunction may contribute to the human disorder Cornelia de Lange syndrome, which is caused by mutations in NIPBL, the human ortholog of SCC2. PMID: 26176819
5. These findings reveal the role of Scc4 in determining the localization of cohesin loading and establish a molecular basis for Scc2/4 recruitment to centromeres. PMID: 26038942
6. After in activation of Scc2, DNA damage specific transcriptional response is distorted. PMID: 25483075
7. Data indicate that Scc2-Scc4 binding sites were strikingly enriched at transcriptional start sites (TSSs). PMID: 25173104
8. These observations suggest a previously unidentified mechanism for the spatiotemporal regulation of cohesin association with chromosomes through cell cycle regulation of Scc2 cohesin deposition activity by Scc2 dephosphorylation and cleavage. PMID: 24778232
9. SMC proteins and Scc2 localize to the silenced domain, and Scc2 binding requires the presence of gamma-H2A. PMID: 23733345
10. Scc2 is required for activating the expression of REC8 and Scc2 is necessary for recruiting meiotic cohesin to the chromosome to generate sister-chromatid cohesion. PMID: 21508318
11. Scc2/Scc4 resides at previously mapped cohesin-associated regions (CARs) in pericentromeric and arm regions, and that Scc2/Scc4-cohesin colocalization persists after the initial deposition of cohesins in G1/S phase PMID: 19797771
12. Mutations in Scc2 may affect the loading or dynamics of cohesin, condensin, or both. PMID: 19948494

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KEGG: sce:YDR180W

STRING: 4932.YDR180W