SGS1 Antibody

1. These studies collectively illustrate that Sgs1 participates in both branches of DNA-damage tolerance and possibly plays a role in pathway choice PMID: 28918480
2. Recently, we and others have uncover a direct link between the Smc5/6 complex and Sgs1. Most roles of Sgs1 during recombination, including DNA end resection, Holiday junction dissolution, and crossover suppression, are regulated through Mms21-dependent SUMOylation PMID: 27664093
3. Sgs1 and BLM regulate R-loop-associated genome instability. PMID: 29042409
4. Double deletion of Sgs1 and Mph1 abolishes the REC-mediated lag observed during the repair of large gaps and break-induced replication substrates. PMID: 27075725
5. Sgs1 mutants impaired in recognition of SUMOylated Smc5/6 (sgs1-SIMDelta) or SUMO-dead alleles (sgs1-KR) exhibit unprocessed HJs at damaged replication forks, increased crossover frequencies during double-strand break repair, and severe impairment in DNA end resection PMID: 27298337
6. The role of Sgs1 in crossover formation during meiotic recombinational repair PMID: 25329811
7. Sgs1 unwinds trinucleotide repeat hairpin completely by translocation mediated unwinding. PMID: 26004439
8. Escape of Sgs1 from Rad9 inhibition reduces the requirement for Sae2 and functional MRX in DNA end resection. PMID: 25637499
9. Mutation of the Sgs1 helicase impairs recombination and meiosis. Deletion of the Top3 interaction domain of Sgs1 causes a top3-like phenotype. PMID: 18272435
10. resection processivity defect in sgs1-D664Delta cells alters affinity of DNA ends for HR proteins. PMID: 24097410
11. Identification of a short segment within the first 125 residues of the intrinsically disordered N-terminus of unbound Sgs1 that has transient alpha-helical structure whose integrity is essential for Sgs1 function in vivo. PMID: 24038467
12. Checkpoint activation in G1 requires the catalytic activity of Sgs1, suggesting that it is DNA resection mediated by Sgs1 that stimulates the damage response pathway. PMID: 23835406
13. The hDNA data are consistent with the proposed role of Sgs1 in the dissolution of double Holliday junction (HJs), and we propose that Srs2 dismantles nicked HJs. PMID: 23516370
14. Sgs1 is required for dsDNA unwinding and, unexpectedly, also has a structural role in DNA strand passage. PMID: 22885009
15. Sgs1 is a primary regulator of recombination pathway choice during meiosis and suggest a similar function in the mitotic cell cycle. PMID: 22500736
16. These data reveal Sgs1 as a central regulator and mediator of meiotic Holliday junction-containing joint molecules resolution, with unanticipated roles in both noncrossover and crossover formation. PMID: 22500800
17. Sgs1 plays a role in transcriptional regulation and acts as a repressor of a subset of rapamycin responsive genes. PMID: 21639830
18. Study provides evidence that Sgs1 interacts with various partner proteins to maintain genome stability throughout meiosis. PMID: 21085703
19. the Helicase/RNase D C-terminal domain and the Rad51 interaction domain are dispensable for Sgs1's role in suppressing genome instability, whereas the zinc-binding domain and the helicase domain are required PMID: 21111748
20. a sub-domain of the Sgs1 N-terminus that shows in vitro single-strand DNA (ssDNA) binding, ssDNA annealing and strand-exchange (SE) activities PMID: 20389284
21. full-length Sgs1 binds diverse single-stranded and double-stranded DNA substrates, including DNA duplexes with 5'- and 3'-single-stranded DNA overhangs PMID: 20086270
22. MMR-independent role in the suppression of RAD51-independent recombination. PMID: 15611162
23. identification of two pathways through which Sgs1p contributes to genomic integrity PMID: 15616582
24. Sgs1 associates with Mre11 in different subcomplexes folowing checkpoint activation and CDK1-mediated Srs2 phosphorylation. PMID: 15964827
25. These data support a model in which defects in lagging-strand replication are repaired by the Mus81 endonuclease or through a pathway dependent on Rad51 and Sgs1. PMID: 16193328
26. Sgs1p participates in a RAD52-dependent recombinational pathway of telomere maintenance. PMID: 16428246
27. Sgs1 has helicase-dependent functions in replication and helicase-independent functions in DNA double-strand breaks (DSB) repair by homologous recombination (HR). PMID: 16705162
28. SGS1 suppresses spontaneous, recurring translocations between diverged genes in cells with mutations in the genes encoding the checkpoint proteins Mec3, Rad24, Rad9, or Rfc5, the chromatin assembly factors Cac1 or Asf1, and the DNA helicase Rrm3. PMID: 16809776
29. These findings show that Sgs1 has potent meiotic anti-CO activity, which is normally antagonized by SIC/ZMM proteins. PMID: 17002499
30. the sgs1 rad27 double mutant displayed a shortened replicative lifespan and was also more sensitive to DNA-damaging agents PMID: 17506834
31. Saccharomyces cerevisiae BLM ortholog, Sgs1, prevents aberrant crossing-over during meiosis by suppressing formation of joint molecules (JMs) comprising three and four interconnected duplexes. PMID: 17662941
32. Sgs1 suppresses spontaneous unequal sister-chromatid exchange (SCE), and SGS1 and EXO1 regulate spontaneous SCE by independent mechanisms. PMID: 18166135
33. Sgs1 RecQ helicase inhibits survival of Saccharomyces cerevisiae cells lacking telomerase and homologous recombination PMID: 18757364
34. In the absence of Srs2 or Sgs1, DNA damage accumulates and is processed by homologous recombination, triggering repeat rearrangements. PMID: 19136956
35. Mre11 nuclease interacts with Dna2 plus Sgs1 and has a role in Rad51-dependent recombinational repair PMID: 19165339
36. these results suggest that the Sgs1 function in repair of DNA replication intermediates can be uncoupled from its role in homologous recombinational repair. PMID: 19214189
37. Data show that Sae2 and the Sgs1 RecQ helicase control two distinct but partially complementary pathways for nucleolytic processing telomeres, with Sae2 function requiring its serine 267 phosphorylation. PMID: 19595717

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KEGG: sce:YMR190C

STRING: 4932.YMR190C