sqh Antibody

1. inclusion body myopathy type 3 disease state in heterozygote Drosophila was examined in order to gain a mechanistic understanding of myosin E701K pathogenicity. PMID: 28258125
2. Computer simulation coupled with laser ablation suggests that Dunk-dependent maintenance of cortical myosin enables mechanical tension build-up, thereby providing a mechanism to guide myosin flow and define the hexagonal symmetry of the furrows. PMID: 27226317
3. mechanical forces regulate myosin dynamics during embryonic wound repair. PMID: 28202603
4. the regulation of NMII takes place downstream of guidance receptor signalling and is critical to ensure efficient collective migration. PMID: 27034137
5. Modular activation of Rho1 by GPCR signalling imparts polarized myosin II activation during morphogenesis PMID: 26780298
6. evidence for mechanosensitivity of cell-cell junctions and implications that myosin-mediated tension can prevent Snail-driven Eepithelial-mesenchymal transitions PMID: 26754645
7. Study indicated that Sqh is crucial to regulate the stability of the transcription factor Cubitus interruptus (Ci) in Hedgehog (Hh) pathway. PMID: 26518439
8. flw is a key regulator of basal myosin oscillations and cell contractions underlying egg chamber elongation. PMID: 26888436
9. Expression of myosin RLC variants that prevent or mimic phosphorylation both disrupt axis elongation, but have distinct effects at the molecular and cellular levels. PMID: 25071215
10. A dual role of myosin II in regulating the development of the Drosophila wing, is reported. PMID: 23612302
11. Study generated antibodies against the monophosphorylated (Sqh1P) and diphosphorylated (Sqh2P) forms of Sqh; in imaginal discs, Sqh1P predominantly localizes in the adherens junction, whereas Sqh2P locates to the apical domain. PMID: 20920606
12. apical constriction and invagination of APC null tissue are independent of DE-cadherin elevation, but are dependent on Myosin II activity. PMID: 20102708
13. the movement of myosin II to the contractile ring not only initiates cytokinesis but also completes the partitioning of cell fate determinants from the neuroblast to its daughter. PMID: 14667406
14. Myosin II is specifically enriched in disassembling junctions, and its planar polarized localization and activity are required for planar junction remodelling and cell intercalation PMID: 15190355

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KEGG: dme:Dmel_CG3595

STRING: 7227.FBpp0070842

UniGene: Dm.3