SSB1 Antibody

Code CSB-PA604583XA01SXV

Product Details

Full Product Name Rabbit anti-Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) sks2 Polyclonal antibody
Uniprot No. Q10284
Target Names sks2
Alternative Names Ribosome-associated molecular chaperone sks2 (EC (Heat shock cognate protein hsc1) (Hsp70 chaperone Ssb) (Suppressor of K-252a sensitivity protein 2) sks2 hsc1 SPBC1709.05
Raised in Rabbit
Species Reactivity Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Immunogen Recombinant Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) SSB1 protein
Immunogen Species Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Made-to-order
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Target Data

Function Ribosome-bound, Hsp70-type chaperone that assists in the cotranslational folding of newly synthesized proteins in the cytosol. Stimulates folding by interacting with nascent chains, binding to short, largely hydrophobic sequences exposed by unfolded proteins, thereby stabilizing longer, more slowly translated, and aggregation-prone nascent polypeptides and domains that cannot fold stably until fully synthesized. The Hsp70-protein substrate interaction depends on ATP-binding and on allosteric regulation between the NBD and the SBD. The ATP-bound state is characterized by a fast exchange rate of substrate (low affinity state), while in the ADP-bound state exchange is much slower (high affinity state). During the Hsp70 cycle, the chaperone switches between the ATP-bound state (open conformation) and the ADP-bound state (closed conformation) by major conformational rearrangements involving mainly the lid domain. Ssb cooperates with a specific Hsp40/Hsp70 co-chaperone termed the ribosome-associated complex (RAC), which stimulates the ATPase activity of the ribosome-associated pool of Ssbs and switches it to the high affinity substrate binding state. Hsp110 chaperone pss1 and fes1 act as nucleotide exchange factors that cause substrate release.
Subcellular Location Cytoplasm
Protein Families Heat shock protein 70 family, Ssb-type Hsp70 subfamily
Database Links

KEGG: spo:SPBC1709.05

STRING: 4896.SPBC1709.05.1

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