SSB1 Antibody

Datasheet
Code CSB-PA604583XA01SXV
Product Type Polyclonal Antibody
Uniprot No. Q10284
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) SSB1 protein
Raised in Rabbit
Species Reactivity Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugate
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Ribosome-associated molecular chaperone sks2 (EC 3.6.4.10) (Heat shock cognate protein hsc1) (Hsp70 chaperone Ssb) (Suppressor of K-252a sensitivity protein 2) sks2 hsc1 SPBC1709.05
Immunogen Species Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Gene Names sks2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Ribosome-bound, Hsp70-type chaperone that assists in the cotranslational folding of newly synthesized proteins in the cytosol. Stimulates folding by interacting with nascent chains, binding to short, largely hydrophobic sequences exposed by unfolded proteins, thereby stabilizing longer, more slowly translated, and aggregation-prone nascent polypeptides and domains that cannot fold stably until fully synthesized. The Hsp70-protein substrate interaction depends on ATP-binding and on allosteric regulation between the NBD and the SBD. The ATP-bound state is characterized by a fast exchange rate of substrate (low affinity state), while in the ADP-bound state exchange is much slower (high affinity state). During the Hsp70 cycle, the chaperone switches between the ATP-bound state (open conformation) and the ADP-bound state (closed conformation) by major conformational rearrangements involving mainly the lid domain. Ssb cooperates with a specific Hsp40/Hsp70 co-chaperone termed the ribosome-associated complex (RAC), which stimulates the ATPase activity of the ribosome-associated pool of Ssbs and switches it to the high affinity substrate binding state. Hsp110 chaperone pss1 and fes1 act as nucleotide exchange factors that cause substrate release.
Subcellular Location Cytoplasm
Protein Families Heat shock protein 70 family, Ssb-type Hsp70 subfamily
Database Links

KEGG: spo:SPBC1709.05

STRING: 4896.SPBC1709.05.1

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