TOP3 Antibody

1. Although Top3 and Sgs1 interact without sumoylation, sumoylated forms of Sgs1, particularly those containing K621 conjugates, are preferentially enriched in complexes with Top3. PMID: 27373152
2. Our data are consistent with a redundant role of Top2 and Sgs1 together with Top3 (Sgs1-Top3) in replication fork merging at rDNA barriers. PMID: 26630413
3. Top3-Rmi1 acts in all meiotic recombination functions previously associated with Sgs1, most notably as an early recombination intermediate chaperone, promoting regulated crossover and noncrossover recombination. PMID: 25699707
4. Top3 specifically disrupts D loops mediated by yeast Rad51/Rad54. PMID: 25699708
5. The strand-passage activity of Top3-Rmi1 is required for all known functions of Sgs1 in meiotic recombination, including channeling JMs into physiological crossover and noncrossover pathways, and suppression of non-allelic recombination. PMID: 25699709
6. the roles played by Top3 and the STR complex as a whole during the resolution of replication-associated recombination intermediates. PMID: 24100144
7. Rmi1 has a unique regulatory capacity that slows DNA relaxation by Top3 but stimulates DNA decatenation. PMID: 22885009
8. HJ resolvases and Sgs1-Top3-Rmi1 comprise two independent processes to deal with HJ-containing DNA intermediates arising during HRR in S-phase. PMID: 21383164
9. Study established that Dna2, Sgs1 and RPA constitute a minimal protein complex capable of DNA resection in vitro; in addition it was found that both the Top3 and Rmi1 complex and the Mre11-Rad50-Xrs2 complex have important roles as stimulatory components. PMID: 20811461
10. Loss of the TOP3 gene, encoding topoisomerase III, results in a phenotype of slow growth PMID: 15654096
11. Rmi1 physically interacts with Sgs1 and Top3 and is a third member of this complex. PMID: 15889139
12. The effects of TOP3 on telomere binding in human and S. cerevisiae cells are reported. PMID: 16546998
13. The pif1 top3 mutant combination is synthetic lethal; Pif1-Top3 genetic interaction is recombination dependent. PMID: 16816432
14. We propose that Top3 functions in S phase to both process homologous recombination intermediates and modulate checkpoint activity. PMID: 16899506
15. A model is proposed in which the Shu proteins act in homologous recombination repair(HRR) to promote the formation of HRR intermediates that are processed by the Sgs1-Rmi1-Top3 complex. PMID: 17671161
16. Top3-Rmi1 functions as a complex and suggest that Rmi1 stimulates Top3 by promoting its interaction with ssDNA. PMID: 17693398
17. Mus81.Mms4 together with Rad54 efficiently process perturbed replication forks to promote recovery and may constitute an alternative mechanism to the resolution/dissolution of the recombination intermediates by Sgs1.Top3. PMID: 19129197

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KEGG: sce:YLR234W

STRING: 4932.YLR234W