Trim33 Antibody

1. Data show that tripartite motif 33 (TRIM33) mediates Wnt signaling by directly regulating the expression of a specific subset of Wnt target genes. PMID: 28844090
2. Trim33 is thus revealed as being essential for the navigation of macrophages and neutrophils towards developmental or inflammatory cues within vertebrate tissues. PMID: 28724755
3. Study reveals new important functions of TRIM33 in macrophage production and activation by LPS and pinpoints TRIM33 as an important transcriptional actor of monocyte/macrophage mediated inflammation. PMID: 27974684
4. TRIM33 is necessary for osteoblast proliferation by regulating cell cycle and for differentiation via bone morphogenetic protein signaling pathway. PMID: 28063228
5. these results indicate that Trim33 deficiency leads to the expansion of a subset of myeloid cells characterizing the myelodysplastic/myeloproliferative neoplasm. PMID: 27130375
6. Trim33 altered expression of a small group of genes in the testis and the gene with the most significant increase was transcribed from an upstream RLTR10B. PMID: 26624618
7. TRIM33 deficiency results in high expression of Ifnb1 at late stages of macrophages activation. PMID: 26592194
8. our work indicates that TIF1gamma exerts its tumor-suppressive functions in part by promoting chromosomal stability. PMID: 26282171
9. The findings reveal an essential role for TRIM33 in preventing apoptosis in B lymphoblastic leukemia by interfering with enhancer-mediated Bim activation. PMID: 25919951
10. This study demonistrated that Smad4 and Trim33 regulate neural stem cells in the developing cortex in mice. PMID: 23765158
11. Epithelium-specific Tak1:Smad4- and Trim33:Smad4-double mutants display reduced expression of Mmp13 in palatal medial edge epithelial cells. PMID: 25523394
12. The dermatomyositis autoantigen TIF1gamma is markedly up-regulated during muscle regeneration in human and mouse muscle cells. PMID: 25186009
13. reduces invasion and metastasis of hepatocellular carcinoma cells PMID: 24954480
14. These data provide a new paradigm for Tif1gamma in regulating the balance between lymphoid- and myeloid-derived hematopoietic stem cells (HSC) through TGF-beta signaling, leading to HSC aging. PMID: 25002492
15. TIF1gamma plays essential roles in multiple murine blood lineages and that its function in transcription elongation is evolutionally conserved. PMID: 23159334
16. Tif1gamma suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway. PMID: 22469842
17. Study reports an essential role for TRIM33 in the activation of Gsc and Mixl1 by nodal signals, and delineate how Smads gain access to poised promoters of master regulators under the command of nodal TGF-beta signals. PMID: 22196728
18. Loss of Tif1g in mouse HSCs favored the expansion of the granulo-monocytic progenitor compartment & induced the age-dependent appearance of a cell-autonomous myeloproliferative disorder resembling human CMML. PMID: 21537084
19. Somatic hepatocyte-specific inactivation of TRIM24, TRIM28, or TRIM33 all promote hepatocellular carcinoma in a cell-autonomous manner in mice. PMID: 21531907
20. intracellular negative control of Smad function by ectodermin/Tif1gamma is a crucial element in the cellular response to TGFbeta signals in mammalian tissues PMID: 20573697
21. transcriptional intermediary factor has a major role in the differentiation of hematopoietic cells PMID: 15314655
22. Generation of mice with conditional allele for Trim33 is reported. PMID: 18543301
23. In a mouse model, study showed that Tif1gamma was dispensable for normal pancreatic development but cooperated with Kras activation to induce pancreatic tumors reminiscent of human Intraductal Papillary Mucinous Neoplasms (IPMNs). PMID: 19629168

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KEGG: mmu:94093

STRING: 10090.ENSMUSP00000029444

UniGene: Mm.195036