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Human Cystatin-SN(CST1) ELISA kit

Human Cystatin-SN(CST1) ELISA kit

Citations (9) Protocol MSDS

Code	CSB-EL006088HU
Size	96T,5×96T,10×96T
Price	Request a Quote
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Product Details
Citations (9)
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Alternative Names

CST1 ELISA Kit; Cystain SAI ELISA Kit; Cystain-SA-I ELISA Kit; Cystatin 1 ELISA Kit; Cystatin-1 ELISA Kit; Cystatin-SN ELISA Kit; Cystatin1 ELISA Kit; Cysteine proteinase inhibitor, type 2 family ELISA Kit; CYTN ELISA Kit; CYTN_HUMAN ELISA Kit; Salivary cystatin SA1 ELISA Kit; Salivary cystatin-SA-1 ELISA Kit

Abbreviation

CST1

Uniprot No.

P01037

Species

Homo sapiens (Human)

Sample Types

serum, plasma, cell culture supernates,urine, tissue homogenates, cell lysates

Detection Range

0.156 ng/mL-10 ng/mL

Sensitivity

0.039 ng/mL

Assay Time

1-5h

Sample Volume

50-100ul

Detection Wavelength

450 nm

Research Area

Cell Biology

Assay Principle

quantitative

Measurement

Sandwich

ELISA Data Analysis

ELISA Standard Curve & Curve Expert software

Troubleshooting
and FAQs

ELISA kit FAQs

Storage

Store at 2-8°C. Please refer to protocol.

Shelf Life

6 months

Lead Time

3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx.

Description

This Human CST1 ELISA Kit was designed for the quantitative measurement of Human CST1 protein in serum, plasma, cell culture supernates,urine, tissue homogenates, cell lysates. It is a Sandwich ELISA kit, its detection range is 0.156 ng/mL-10 ng/mL and the sensitivity is 0.039 ng/mL .

Citations

Cystatin C and cystatin SN as possible soluble tumor markers in malignant uveal melanoma MA Dikovskaya,Radiology and oncology,2023
The Cystatin C and cystatin SN as possible soluble tumor markers in malignant uveal melanoma T Korolenko,Radiology and oncology,2023
Epithelial CST1 Promotes Airway Eosinophilic Inflammation in Asthma via the AKT Signaling Pathway X Lisha,e-aair,2023
Multi-omics profiling reveals that eating difficulties developed consecutively to artificial nutrition in the neonatal period are associated to specific saliva composition Morzel M. et al,J Proteomics,2015
P43 : Endogenous inhibitors of cysteine proteases cystatin C and cystatin SN in biological fluids of patients with intraocular melanoma as possible biomarkers and therapy targets M. Dikovskaya. et al,European Journal of Cancer Supplements,2015
Salivary Composition Is Associated with Liking and Usual Nutrient Intake Méjean C. et al,PLoS One,2015
Identification of cystatin SN as a novel biomarker for pancreatic cancer. Jiang J.et al,Tumour Biol.,2015
Endogenous inhibitors of cysteine proteases cystatin C and cystatin SN in biological fluids of patients with intraocular melanoma as possible biomarkers and therapy targets Dikovskaya M.et al,EJC Supplements,2015
Caffeine increases the expression of cystatin SN in human submandibular acinar-like HSG cells Dsamou M et al,Arch Oral Biol,2013

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function
(From Uniprot)

Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.

Gene References into Functions

Results revealed that CST1 expression was upregulated in colon cancer (CC) compared with normal tissues and contributed to CC cell proliferation. PMID: 29845224
High CST1 expression is negatively correlated with survival of breast cancer patients. CST1 promotes cell proliferation, clone formation, and metastasis in breast cancer cells. CST1 is a novel potential prognostic biomarker and therapeutic target for breast cancer. PMID: 28523467
this results identified cystatin 1 as a biomarker in patients with seasonal allergic rhinitis PMID: 28633877
These results indicate that CST1-mediated extracellular CatB activity enhances tumor development by preventing cellular senescence. PMID: 28383558
interactions of human family 1 & 2 cystatins with cathepsin L1 PMID: 27764212
high expression of Cystatin SN is a significant prognostic indicator of a higher rate of recurrence, metastatic risk, and poor survival in patients with surgically resected NSCLCs. PMID: 25648368
In conclusion, our data suggest that CST1 might contribute to the proliferation of pancreatic cancer cells and could be a potential biomarker for the early detection of pancreatic cancer. PMID: 25577248
CST1 may contribute to inactivation of protease allergens and help re-establish homeostasis of the nasal membranes. PMID: 23950865
CST1 expression at both the messenger RNA and protein levels was barely detected in control cells, which included early passage proliferating, quiescent, or immortal human fibroblasts PMID: 21636832
Murine monoclonal antibodies were made which can distinguish between CST1 and CST2. PMID: 15829315
CST1 might be highly involved in gastric tumorigenesis and regulate the proteolytic activity of cysteine proteases. PMID: 19463800
Identification of Cystatin SN as a novel tumor marker for colorectal cancer. PMID: 19513549

Hide All

Subcellular Location

Secreted.

Protein Families

Cystatin family

Tissue Specificity

Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid.

Database Links

HGNC: 2473

OMIM: 123855

KEGG: hsa:1469

STRING: 9606.ENSP00000305731

UniGene: Hs.123114

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ELISA Data Analysis How to Do The Pre-experiment before Your ELISA Experiment Four Types of ELISA 11 tips for choosing your right ELISA kit Do you Often Trouble in These Problems of ELISA? Problems and Solutions in ELISA Experiments

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Human Cystatin-SN(CST1) ELISA kit

Product Details

Citations

Related Products

Customer Reviews and Q&A

Target Background