CST1 Antibody

Code CSB-PA963535
Size US$297Purchase it in Cusabio online store
(only available for customers from the US)
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  • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using CST1 antibody.
  • Immunofluorescence analysis of MCF-7 cells, using CST1 antibody.
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) CST1 Polyclonal antibody
Uniprot No. P01037
Target Names CST1
Alternative Names CST1 antibody; Cystain SAI antibody; Cystain-SA-I antibody; Cystatin 1 antibody; Cystatin-1 antibody; Cystatin-SN antibody; Cystatin1 antibody; Cysteine proteinase inhibitor, type 2 family antibody; CYTN antibody; CYTN_HUMAN antibody; Salivary cystatin SA1 antibody; Salivary cystatin-SA-1 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Synthesized peptide derived from internal of Human CST1.
Immunogen Species Homo sapiens (Human)
Clonality Polyclonal
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications ELISA,IHC,IF
Recommended Dilution
Application Recommended Dilution
IHC 1:50-1:100
IF 1:100-1:500
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.
Gene References into Functions
  1. Results revealed that CST1 expression was upregulated in colon cancer (CC) compared with normal tissues and contributed to CC cell proliferation. PMID: 29845224
  2. High CST1 expression is negatively correlated with survival of breast cancer patients. CST1 promotes cell proliferation, clone formation, and metastasis in breast cancer cells. CST1 is a novel potential prognostic biomarker and therapeutic target for breast cancer. PMID: 28523467
  3. this results identified cystatin 1 as a biomarker in patients with seasonal allergic rhinitis PMID: 28633877
  4. These results indicate that CST1-mediated extracellular CatB activity enhances tumor development by preventing cellular senescence. PMID: 28383558
  5. interactions of human family 1 & 2 cystatins with cathepsin L1 PMID: 27764212
  6. high expression of Cystatin SN is a significant prognostic indicator of a higher rate of recurrence, metastatic risk, and poor survival in patients with surgically resected NSCLCs. PMID: 25648368
  7. In conclusion, our data suggest that CST1 might contribute to the proliferation of pancreatic cancer cells and could be a potential biomarker for the early detection of pancreatic cancer. PMID: 25577248
  8. CST1 may contribute to inactivation of protease allergens and help re-establish homeostasis of the nasal membranes. PMID: 23950865
  9. CST1 expression at both the messenger RNA and protein levels was barely detected in control cells, which included early passage proliferating, quiescent, or immortal human fibroblasts PMID: 21636832
  10. Murine monoclonal antibodies were made which can distinguish between CST1 and CST2. PMID: 15829315
  11. CST1 might be highly involved in gastric tumorigenesis and regulate the proteolytic activity of cysteine proteases. PMID: 19463800
  12. Identification of Cystatin SN as a novel tumor marker for colorectal cancer. PMID: 19513549

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Subcellular Location Secreted.
Protein Families Cystatin family
Tissue Specificity Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid.
Database Links

HGNC: 2473

OMIM: 123855

KEGG: hsa:1469

STRING: 9606.ENSP00000305731

UniGene: Hs.123114

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