Human Osteocalcin/Bone gla protein,OT/BGP ELISA kit

Code CSB-E05128h
Size 96T,5×96T,10×96T
See More Details 24T ELISA kits trial application
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Product Details

Target Name bone gamma-carboxyglutamate (gla) protein
Alternative Names BGLAP ELISA Kit; BGP ELISA Kit; Bone gamma carboxyglutamate (gla) protein ELISA Kit; Bone gamma carboxyglutamate gla protein osteocalcin ELISA Kit; Bone gamma carboxyglutamate protein ELISA Kit; Bone Gla protein ELISA Kit; Gamma carboxyglutamic acid containing protein ELISA Kit; Gamma-carboxyglutamic acid-containing protein ELISA Kit; OC ELISA Kit; OCN ELISA Kit; OSTCN_HUMAN ELISA Kit; Osteocalcin ELISA Kit; OTTHUMP00000016586 ELISA Kit; PMF1 ELISA Kit
Abbreviation BGLAP
Uniprot No. P02818
Species Homo sapiens (Human)
Sample Types serum, plasma, tissue homogenates
Detection Range 31.25 pg/ml-2000 pg/ml
Sensitivity 7.8 pg/ml
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Metabolism
Assay Principle quantitative
Measurement Sandwich
Typical Data  
and FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

Target Data

Function Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
Gene References into Functions
  1. The results of this study suggest that serum osteocalcin is associated with the onset of puberty in girls. PMID: 30089739
  2. The correlation between Mycobacterium avium subsp. paratuberculosis (MAP) infection and elevation of sera ucOC, reduction of active osteocalcin and increased calcium supports MAP infection role in Crohn's disease and complications with osteoporosis. PMID: 29638140
  3. The results showed no significant correlation between osteocalcin HindIII gene polymorphism and bone mineral density (BMD) and therefore osteocalcin HindIII gene polymorphism may not have major effects on BMD variation in postmenopausal North Indian women. PMID: 30179426
  4. Decreased circulating carboxylated osteocalcin is associated with low-energy bone fractures in children. PMID: 29882816
  5. a decrease in serum osteocalcin levels is associated with future development of type 2 diabetes mellitus. PMID: 28766135
  6. Findings from the available data indicated an overall significant inverse association between serum osteocalcin and body mass index--{REVIEW} PMID: 28822067
  7. relatively lower serum osteocalcin levels were associated with a higher risk of MACE in Chinese men with CAD PMID: 28921598
  8. undercarboxylated form of osteocalcin in serum not related significantly to semen parameters or measured hormones in male infertility PMID: 28000970
  9. serum level not correlated with gender, race/ethnicity, age, diabetes type, BMI percentile, random C-peptide, glucose, or HbA1c at pediatric diabetes diagnosis; serum level inversely correlated with HbA1c at first office visit following diagnosis PMID: 28093839
  10. Serum osteocalcin was directly and independently correlated with circulating uric acid in a population of healthy obese subjects. PMID: 28847266
  11. gamma-carboxylation of OCN on Glu17 residue correlates with insulin resistance and subclinical inflammation, suggesting that gamma-carboxylation of OCN negatively regulates its endocrine action PMID: 28242268
  12. There were differences in the associations between total osteocalcin and glucose metabolism in Han and Uygur T2DM patients, indicating genetic factors may play a role in modulating OC and glucose metabolism in different ethnic population. PMID: 28732499
  13. The study demonstrated that undercarboxylated osteocalcin (ucOC) is related to 25(OH)D and adiponectin concentrations. Both ucOC and 25(OH)D were lower in overweight and obese adolescents. PMID: 28443718
  14. Increased advanced glycation end products and protein oxidative damage markers in the course of obesity may contribute to decreased carboxylated osteocalcin serum level. PMID: 28841723
  15. Progressive calcification of atherosclerotic plaques is accompanied by insignificant accumulation of calcitonin and osteoprotegerin, whereas the osteocalcin expression significantly increased during calcification. PMID: 28429221
  16. Undercarboxylated osteocalcin reflects the reserve capacity of beta-cell function, such as the bolus insulin secretion ability in patients with type 2 diabetes. PMID: 27889949
  17. XPS showed that similar amounts of hOC and dhOC were absorbed onto hydroxyapaptite and octacalcium phosphate surfaces, but ToF-SIMS detected some small differences in the amino acid fragment intensities on these surfaces for adsorbed hOC and dhOC. PMID: 28521505
  18. Common polymorphism rs1800247 in osteocalcin gene was associated with hypertension and diastolic blood pressure levels. The association of rs1800247 with hypertension was affected by its interaction with HOMA-IR. PMID: 27251081
  19. These findings indicate the undercarboxylated form of OC is not implicated in age-related changes in skeletal muscle or adipose tissue mass in older community-dwelling adults. PMID: 27604070
  20. Demonstrate a positive association between osteocalcin, a factor known to regulate bone remodelling, with cognitive performance in older non-demented women. PMID: 27515675
  21. Common genetic variants of the osteocalcin gene may not be a major contributor to variations in serum osteocalcin or BMD in postmenopausal and elderly Chinese women. PMID: 28002816
  22. Several detected relations between OCN and metabolites were strongly linked to renal function, however, a number of associations remained significant after adjustment for renal function. Intermediates of proline catabolism were associated with OCN reflecting the implication in bone metabolism. PMID: 28922389
  23. Low serum osteocalcin concentrations are associated with type 2 diabetes. PMID: 27061949
  24. Decreased blood concentration of Carboxylated osteocalcin is associated with metabolic complications and inflammation. PMID: 27667744
  25. Total and undercarboxylated osteocalcin levels were significantly correlated with insulin secretion and insulin resistance indices, but not adiponectin levels, in pregnant women. PMID: 26708046
  26. Osteocalcin and Sex Hormone Binding Globulin Compete on a Specific Binding Site of GPRC6A. PMID: 27673554
  27. Osteocalcin plays an essential role for the maturation of mineral species and modulates osteogenic differentiation of mesenchymal stromal cells (MSCs). PMID: 28106724
  28. Serum osteocalcin levels in pediatric obstructive sleep apnea hypopnea syndrome patients were significantly lower than normal controls before adenotonsillectomy. PMID: 26938749
  29. the relationship between serum osteocalcin and glucose metabolism parameters in liver transplantation recipients, was examined. PMID: 26743527
  30. Reduced plasma Osteocalcin levels are associated with cardiovascular and metabolic diseases. PMID: 26863345
  31. An overview of osteocalcin progress. PMID: 26747614
  32. the BMP-2/Smad1/5/RUNX2 signaling pathway participates in the silicon-mediated induction of COL-1 and osteocalcin synth PMID: 27025722
  33. Data indicate that lower osteocalcin was an independent predictor of worse cognitive performance on multivariate analysis. PMID: 26406918
  34. A common polymorphism rs1800247 in osteocalcin gene may effect the risk of osteoporosis and fracture and serum osteocalcin levels in Chinese. PMID: 26194493
  35. There is an inverse relationship between the visfatin and undercarboxylated osteocalcin in type 2 diabetes patients with diabetic kidney disease. PMID: 26922969
  36. This study investigated osteocalcin, metabolic parameters and anthropometric characteristics in normal weight and overweight/obese children. PMID: 26772621
  37. Nonalcoholic fatty liver disease negatively associated with right-hip bone mineral density and serum osteocalcin in Korean men. PMID: 26636404
  38. The aims of this study were to evaluate OCN and sclerostin levels in subjects who underwent coronary artery bypass graft (CABG) surgery compared with those in normal controls. PMID: 26576474
  39. serum level not associated with weight loss or body fat percentage PMID: 25963022
  40. Serum osteocalcin levels are inversely correlated with nonalcoholic fatty liver disease in postmenopausal Chinese women with normal blood glucose levels. PMID: 26567728
  41. Serum total osteocalcin level is significantly lower in 2 diabetes mellitus patients than controls. PMID: 26372899
  42. Elevated serum preptin and decreased osteocalcin concentrations, together with insulin resistance, are associated with obesity and overweight. PMID: 25675353
  43. gestational diabetes is not associated with osteocalcin, under-carboxylated osteocalin, osteopontin and leptin and does not correlate with insulin resistance. PMID: 25480426
  44. Serum uOC levels in non-dialysis patients with CKD are significantly lower than those in healthy individuals, and uOC is closely associated with subclinical atherosclerosis in CKD patients. PMID: 26381729
  45. Endocrine function of osteocalcin and the cell biology events that allow osteocalcin to become a hormone. [review] PMID: 25577163
  46. Data indicate that higher osteocalcin (OC) or its undercarboxylated form (ucOC) concentration and ucOC to osteocalcin ratio (OCR) were associated with the risk of coronary calcification in men. PMID: 25868823
  47. Data suggest that a low serum osteocalcin level was an independent risk factor for abdominal obesity. PMID: 25871789
  48. Correlation between osteocalcin-positive endothelial progenitor cells and spotty calcification in patients with coronary artery disease PMID: 25644945
  49. These findings unequivocally document that increased vitamin K intake reduces the uncarboxylated form of OCN PMID: 25855755
  50. Serum osteocalcin level was not independently associated with C-IMT in a metabolically healthy Chinese population. PMID: 26077201
  51. In obese patients, osteocalcin levels decreased after a hypocaloric diet. PMID: 26166639
  52. ucOC(Undercarboxylated osteocalcin ) showed an inverse correlation with markers of insulin resistance, central obesity, and the presence of MetS ( metabolic syndrome ) in postmenopausal women and appears to protect against MetS ( metabolic syndrome ). PMID: 25716667
  53. findings indicate the association between serum osteocalcin and glucose metabolism and beta cell function; no relationship was found between osteocalcin and insulin resistance and lipid metabolism in type 2 diabetes PMID: 25721846
  54. Data suggest that serum biomarkers of low bone turnover (osteocalcin; CrossLaps peptide/CTX; procollagen type 1 N-terminal propeptide/PINP) are down-regulated in subjects with metabolic syndrome and diabetes type 2. PMID: 25816734
  55. A reduced proportion of undercarboxylated osteocalcin or higher N-terminal propeptide of type I collagen are associated with increased incidence of myocardial infarction. PMID: 26308289
  56. exercise-induced body fat reduction and improved insulin sensitivity were accompanied by an increase in serum osteocalcin and leptin levels PMID: 25174991
  57. Osteocalcin has a role in the pituitary-gonadal axis in older men PMID: 25376262
  58. These findings for the first time suggest that genetic variant in osteocalcin gene rs1800247 polymorphisms may be a risk factor for hepatitis B-related hepatocellular carcinoma. PMID: 25587715
  59. Serum total osteocalcin level was not associated with the development of cardiovascular disease. PMID: 25195811
  60. cross-linked C-telopeptide of type 1 collagen, body mass index, creatinine, Sema3A, bone mineral densities, and age were determinants of Ocn PMID: 25050899
  61. Serum osteocalcin is negatively associated with weight BMI and fasting plasma glucose in healthy Chinese women. PMID: 25327813
  62. In chronic kidney disease, patients with mitral annular calcification had higher serum osteocalcin levels. PMID: 25224152
  63. in type 1 diabetes of long duration, OC serum levels are inversely associated with HbA1c and BMI, supporting the hypothesis that a poor glycemic control can affect osteoblast function. PMID: 24859912
  64. Data suggest that serum osteocalcin levels are down-regulated in newly diagnosed, middle-aged, Tibetan men with different degrees of glucose tolerance in association with poorer insulin resistance and poorer pre-treatment control of blood glucose. PMID: 24339141
  65. No correlation between total osteocalcin and fasting plasma glucose, fasting insulin and insulin resistance parameters was found in nondiabetic postmenopausal women. Serum levels of adiponectin were associated with metabolic syndrome. PMID: 24852846
  66. Effect of cyclic mechanical stimulation on the expression of osteogenesis genes in human intraoral mesenchymal stromal and progenitor cells. PMID: 24804200
  67. Data indicate that Ca2+ binding triggered a similar conformational transition in both gamma-carboxyglutamic acid-containing protein osteocalcin (Gla-OCN) and Glu-OCN from a disordered structure to a more compact/stable form. PMID: 24896339
  68. Osteocalcin might improve glucose metabolism through enhancing insulin secretion in males, and through increasing insulin secretion and improving insulin resistance in females with type 2 diabetes mellitus. PMID: 24785155
  69. In this review, we summarize the current knowledge on osteocalcin functions, its various modes of action and the mechanisms implicated in the control of this hormone. [review] PMID: 24893146
  70. OC follows a gene duplication strategy while MGP variability was obtained mostly by the use of multiple promoters and alternative splicing, leading to proteins with additional functional characteristics and alternative gene regulatory pathways. [review] PMID: 25068814
  71. protective action of osteocalcin against the development of insulin resistance and type 2 diabetes in women may be partially mediated through up-regulation of adiponectin secretion PMID: 24405382
  72. We found that one bout of severe eccentric contractions caused increases in osteocalcin and TRACP-5b PMID: 24583540
  73. The undercarboxylated form of OC is related to common cardiovascular risk markers in children at risk for cardiovascular disease. PMID: 24529156
  74. Serum osteocalcin is associated with indices of obesity and HDL level in men PMID: 24465160
  75. In older Caucasian men, total osteocalcin level was associated with metabolic syndrome severity. Osteocalcin was more strongly associated with MetS severity than other bone turnover markers. PMID: 24842726
  76. A higher plasma OC concentration was associated with a reduced risk of CVD in older-old men and with an increased risk of CVD in older-old women. PMID: 24801588
  77. Total OC and carboxylated OC showed less pronounced decrease during the oral glucose tolerance test in obese subjects compared with controls, whereas other bone turnover markers responded similarly in the two groups. PMID: 24606073
  78. The uncarboxylated to carboxylated index of osteocalcin is low in type 2 diabetes patients. PMID: 24113735
  79. Activation of IGF-1R can induce apoptosis in adipose-derived stem cells, whereas it can be prevented by the A20 and osteocalcin expression. PMID: 24219294
  80. Engineered a recombinant human osteocalcin (rhOC) with FN type III9-14 (rhOC-FNIII9-14) containing RGD and HBD to promote the cellular activity of MC3T3-E1 cells, including adhesion, proliferation, and differentiation. PMID: 24078129
  81. an inverse association between serum ferritin and sTfR with osteocalcin and extend previous results on adiponectin, thus supporting that factors related to iron metabolism could contribute to the insulin resistance and the development of type 2 diabetes PMID: 24167545
  82. Data suggest plasma osteocalcin can be regulated by diet; osteocalcin levels are lower with high-protein/high-glycemic index (GI) diet than with low-protein/high-GI diet after 6-month family intervention in children/adolescents of overweight parents. PMID: 24503413
  83. There are 3 ERRalpha response elements (ERR response element, ERRE) in the osteocalcin promoter, and ERRalpha interacted cooperatively with PGC-1alpha could improve the osteocalcin promoter activity. PMID: 23788330
  84. Results indicate a significant correlation between Glu-OC and assessed markers of bone metabolism. 2. Research has indicated a link between bone metabolism and the degree of calcification in the coronary arteries. PMID: 24455828
  85. Circulating UC-OCN was increased while C-OCN was decreased in treatment-naive females with metabolic syndrome. PMID: 23512417
  86. In a population at high cardiovascular risk, low concentrations of serum carboxylated OC and uccarboxylated OC were strongly associated with an increased risk of incident diabetes. PMID: 24037881
  87. Data suggest that lower serum OCN is associated with metabolic syndrome (MS); serum OCN is inversely associated with body mass index, waist circumference, and hypertension, suggesting that OCN plays a part in development/progression of MS/overweight. PMID: 23485732
  88. Our study indicates that the serum ucOC decreases with age in men, increases postmenopausally in women, and correlates inversely with dietary consumption of certain foods and with fasting glucose and HbA1c level. PMID: 23001602
  89. Data do not support the notion that osteocalcin is associated with male fertility in young men from infertile couples. PMID: 23696116
  90. Serum osteocalcin is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes. PMID: 23342952
  91. Osteocalcin may play a protective role in the pathogenesis of type 2 diabetes PMID: 22978420
  92. Data from overweight/obese patients suggest that serum total OC is associated with skeletal muscle but not hepatic insulin resistance; undercarboxylated OC is associated with islet beta-cell function only in individuals with impaired fasting glucose. PMID: 23616149
  93. Osteocalcin is released from platelet granules and is expressed and released at a higher concentration in patients with carotid artery occlusive disease. PMID: 23206207
  94. Data suggest that serum level of total osteocalcin during the follicular phase is positively associated with fat-free mass in healthy premenopausal women. PMID: 23553865
  95. Is there an association between insulin resistance and serum osteocalcin (or adiponectin) levels? Data from obese children/adolescents in Turkey suggest no association between serum osteocalcin (or adiponectin) levels and insulin resistance. PMID: 23261860
  96. Higher baseline total osteocalcin concentrations were associated with lower abdominal aorta calcification progression rate and lower mortality. PMID: 23386651
  97. serum osteocalcin levels were independently associated with glucose intolerance and abdominal obesity, which are components of metabolic syndrome, and type 2 diabetes mellitus in postmenopausal women in Iran PMID: 22752126
  98. High Serum undercarboxylated osteocalcin level is associated with response to therapy in rheumatoid arthritis. PMID: 23135318
  99. A significant increase of osteocalcin after physical exercise was found in subjects with adrenal incidentaloma. PMID: 22652825
  100. the polymorphic genotypes of BGLAP, ER1, Col1A1 and CALCR are not found to be associated with osteoporosis in a single form but found to be associated in combined forms. PMID: 23137636

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Subcellular Location Secreted
Protein Families Osteocalcin/matrix Gla protein family
Database Links

HGNC: 1043

OMIM: 112260

KEGG: hsa:632

STRING: 9606.ENSP00000357255

UniGene: Hs.654541

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