Human Protein FAM3C(FAM3C) ELISA kit

Code CSB-EL008228HU
Size 96T,5×96T,10×96T
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Product Details

Alternative Names
Fam3c ELISA Kit; FAM3C_HUMAN ELISA Kit; Family with sequence similarity 3 member C ELISA Kit; GS3786 ELISA Kit; ILEI ELISA Kit; Interleukin-like EMT inducer ELISA Kit; Predicted osteoblast protein ELISA Kit; Protein FAM3C ELISA Kit
Abbreviation
FAM3C
Uniprot No.
Species
Homo sapiens (Human)
Sample Types
serum, plasma, tissue homogenates
Detection Range
1.56 ng/ml - 100 ng/ml
Sensitivity
0.39 ng/ml
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Immunology
Assay Principle
quantitative
Measurement
Sandwich
Troubleshooting
and FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx

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Target Background

Function
(From Uniprot)
May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.
Gene References into Functions
  1. The ILEI appears to play a crucial role in mediating TGF-beta1-induced EMT through the Akt and ERK pathways, which may provide a therapeutic target for the treatment of fibrotic kidney diseases. PMID: 29336056
  2. Covalent dimerization of ILEI is associated with breast cancer metastasis. PMID: 28837266
  3. Data suggest that ILEI does not form interleukin-like four helix-bundle structures; ILEI exists as monomers and as covalent dimers; ILEI dimer exhibits a trans-linked domain swap converting an intramolecular disulfide to an intermolecular disulfide; dimeric ILEI appears to be involved in neoplastic invasiveness. PMID: 28751379
  4. Results demonstrate that phenotype switching regulates ILEI expression, and that ILEI regulates partial phenotype switching in MITF-low melanoma cell lines. PMID: 28545079
  5. Ectopic overexpression of UBE4A, but not UBE3C, in cells was downregulated in vitro migration and invasion in these cells. Cumulatively, our data reveals a novel post-translational regulatory mechanism of regulating ILEI1 expression, a protein required for metastatic progression in prostate cancer cells PMID: 27862841
  6. Study used immunohistochemical staining and biochemical fractionation to examine the regional distribution and subcellular localization of ILEI in mouse brains and in autopsy brains of patients with Alzheimer's disease; results suggest that a decline of ILEI expression may cause accumulation of Abeta in the brain and the eventual development of Alzheimer's disease. PMID: 27256505
  7. FAM3C expression was dramatically increased in esophageal squamous cell carcinoma and might serve as a valuable prognostic indicator for esophageal squamous cell carcinoma patients after surgery PMID: 26498278
  8. Altered subcellular ILEI localization strongly correlates with high tumor cell-associated uPAR protein expression. PMID: 25212966
  9. Our findings indicate that cytoplasmic ILEI expression is a potential marker of EMT and tumour progression in colorectal cancer. ILEI is an independent predictive factor associated with poor prognosis in colorectal cancer. PMID: 24738665
  10. ILEI could induce, as well as maintain, CD24(low)CD44(high) subpopulation in A549 cells treated with TGF-beta, which might explain its capability to induce metastatic progression. PMID: 24072492
  11. At the FAM3C gene locus where rs7776725 was located, we identified several other SNPs (rs4727922, rs1803389, rs718766 and rs7793554) that were also associated with BMD. PMID: 22159821
  12. A cytokine-like protein found in almost all tissues. PMID: 12160727
  13. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors. PMID: 16959614
  14. Data show that FAM3C is decreased in the CSF of temporal lobe epilepsy patients. PMID: 19109932

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Subcellular Location
Secreted. Cytoplasmic vesicle. Note=Cytoplasmic in some cancer cells.
Protein Families
FAM3 family
Tissue Specificity
Present in most secretory epithelia (at protein level).
Database Links

HGNC: 18664

OMIM: 608618

KEGG: hsa:10447

STRING: 9606.ENSP00000353025

UniGene: Hs.272375

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