Human Protein kinase C-binding protein NELL1(NELL1) ELISA kit

1. Results show that NELL1 methylation level was 6.8% higher in renal cell cancer (RCC) tissues associated with advanced disease of distant metastases, and shorter RFS. Analyses suggested that NELL1 DNA methylation is a promising candidate prognostic epigenetic biomarker for more detailed analyses of RCC disease. PMID: 30272321
2. This work indicates that NELL-1, HMGB1, and CCN2 might enhance bone defect healing via the recruitment of endogenous cells and induction of vascularization and act via different processes than BMP2. PMID: 28463604
3. NELL1 variant is associated with tobacco- and HPV-mediated oral oncogenesis. PMID: 30091681
4. Results demonstrate that NELL1 is differentially expressed in fusion-positive alveolar rhabdomyosarcoma (ARMS) and in embryonal rhabdomyosarcoma (ERMS) samples, and they show that this transcriptional difference partially depends on genomic DNA methylation. The study also found that high NELL1 levels are correlated with negative RMS prognostic factors and with poor tumor outcomes. PMID: 28380437
5. lipoaspirate-derived hPSCs present a novel and abundant cell source of MSCs for cartilage regeneration, and the combinatorial application of NELL-1, TGF-beta3, and BMP-6 with hPSCs may remarkably enhance and accelerate cartilage repair. PMID: 26700847
6. establish the feasibility of combining NELL-1 with BMP2 to improve clinical bone regeneration and provide mechanistic insight into canonical Wnt pathway activity during NELL-1 and BMP2 osteogenesis PMID: 26772960
7. Data suggest that TSPN (N-terminal thrombospondin-1-like) domain of NELL1 exhibits major heparin-binding sites which may be involved in interaction of NELL1 with cell surface heparan sulfate proteoglycans. PMID: 26627376
8. NELL-1 signaling activates Wnt/beta-catenin signaling. PMID: 26082355
9. We also detected lower relative expression of Nell-1 by real-time PCR. Furthermore, immunohistochemical analyses revealed that Nell-1 staining was less intense in cancer tissue relative to normal tissue and that the tumor cells had spread to the muscle PMID: 26090379
10. CpG islands in the NELL1 and NELL2 promoters are hypermethylated in renal cell carcinoma.NELL1 and NELL2 protein expression is downregulated in clear cell renal carcinoma. PMID: 25726761
11. NELL-1 demonstrates diffuse and reliable expression in benign but not malignant bone-forming skeletal tumors PMID: 25791475
12. NELL1 overexpression greatly enhanced the osteogenic differentiation and mineral synthesis of iPSC-MSCs on RGD-grafted CPC scaffold for the first time. PMID: 25220281
13. Two single-nucleotide polymorphisms of the NELL1 gene may represent a novel mechanism underlying hydrochlorothiazide-induced adverse metabolic effects (meta-analysis). PMID: 23400010
14. NELL1 is able to promote the osteogenic differentiation of periodontal ligament stem cells, which may be related to the downregulation of Msx2 expression. PMID: 22767336
15. Activation of the JNK pathway is necessary to mediate terminal osteogenic different-iation of Saos-2 osteosarcoma cells by rhNELL-1. PMID: 22797704
16. Data indicate that LvNELL1 infection promoted the osteogenic differentiation of hADSCs, and the effect was comparable with that of LvBMP2. PMID: 23017834
17. SHH and NELL-1 directed signaling produced additive effects on the pro-osteogenic and antiadipogenic differentiation of adipose derived stem cells. PMID: 22264144
18. Prediction of radiographic severity in Ankolysing Spondylitis based on clinical variables can be significantly improved by including SNPs at ADRB1 (rs1801253), NELL1 (rs8176785) and MHC (rs1634747, rs9270986, rs7451962 and rs241453) genes. PMID: 22495925
19. These results identify one potential mechanism of action for rhNELL-1 induced osteogenesis and highlight a fundamental difference between NELL-1 and BMP-2 signaling. PMID: 22580275
20. NELL-1 may produce functional cartilage with properties similar to native cartilage. PMID: 21902605
21. Results suggest that Osterix is a direct transcriptional regulator with repressive effect on NELL-1 gene expression, contributing to a delicate balance of regulatory effects on NELL-1 transcription with Runx2. PMID: 21931789
22. Nell-1 is a candidate growth factor able to induce pericyte osteogenic differentiation. PMID: 21615216
23. the effects of NELL-1 on osteoblastic differentiation and proliferation are partly through binding to APR3 PMID: 21723284
24. The osteogenic effects of NELL1 on femoral distraction osteogenesis, was investigated. PMID: 20959151
25. a potent growth factor that is highly specific to the osteochondral lineage, and has demonstrated robust induction of bone in multiple in vivo models [review] PMID: 20647499
26. Data indicate that NELL1 is a ubiquitous inflammatory bowel disease susceptibility locus. PMID: 17684544
27. Runx2 directly binds to the osteoblast specific binding elements 2 elements and transactivates the human NELL-1 promoter. PMID: 17042739
28. Promoter hypermethylation of NELL1 is a common, tissue-specific event in human EAC, occurs early during Barrett's-associated esophageal neoplastic progression, and is a potential biomarker of poor prognosis in early-stage EAC PMID: 17452981
29. findings suggest that upon binding to a specific receptor NELL1 transduces an osteogenic signal through activation of certain Tyr-kinases associated with the Ras-MAPK cascade, and finally leads to the osteogenic differentiation PMID: 18082140
30. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18519826
31. Transgenic mice overexpressing Nell-1 develop craniosynostosis. PMID: 12235118

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HGNC: 7750

OMIM: 602319

KEGG: hsa:4745

STRING: 9606.ENSP00000349654

UniGene: Hs.657172