Human Tenascin-c (TNC) ELISA Kit

Code CSB-E13125h
See More Details 24T ELISA kits trial application
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Product Details

Target Name Tenascin-c
Alternative Names 150 225 ELISA Kit; Cytotactin ELISA Kit; Glioma associated extracellular matrix antigen ELISA Kit; Glioma-associated-extracellular matrix antigen ELISA Kit; GMEM ELISA Kit; GP 150 225 ELISA Kit; GP 150-225 ELISA Kit; GP ELISA Kit; Hexabrachion ELISA Kit; HXB ELISA Kit; JI ELISA Kit; MGC167029 ELISA Kit; Miotendinous antigen ELISA Kit; Myotendinous antigen ELISA Kit; Neuronectin ELISA Kit; TENA_HUMAN ELISA Kit; Tenascin ELISA Kit; Tenascin-C ELISA Kit; Tenascin-C isoform 14/AD1/16 ELISA Kit; TenascinC ELISA Kit; TN ELISA Kit; TN C ELISA Kit; TN-C ELISA Kit; TNC ELISA Kit
Abbreviation TNC
Uniprot No. P24821
Species Homo sapiens (Human)
Sample Types
Detection Range
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Cardiovascular
Typical Data  
and FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

Target Data

Function Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells
Gene References into Functions
  1. In addition, we found that Tn-expressing colorectal cancers (CRC) cell lines had either loss-of-function mutations in Cosmc or reversible Tn antigen expression, which was not caused by the deficiency of T-synthase activity PMID: 30115016
  2. The results demonstrated that ANX2 and stromal tenascin C regulated invasion in addition to stemness and anoikis resistance, which are crucial for metastasis in the progression of pancreatic ductal adenocarcinoma. PMID: 29749431
  3. Intratumor stromal expression of tenascin-C (TN-C) is a strong prognostic indicator in locally advanced unresectable (UR-LA) pancreatic ductal adenocarcinoma (PDAC) patients with resection after chemoradiotherapy (CRT). PMID: 29517632
  4. this study shows that tenascin C is increased in vitiligo in lesional areas only in the acral sites PMID: 29605863
  5. Data indicate three sites within tenascin-C that directly and cooperatively interact with toll-like receptor 4 (TLR4). PMID: 29150600
  6. Results identify tenascin-C as an endogenous danger signal that is upregulated in systemic sclerosis and drives TLR4-dependent fibroblast activation, and by its persistence impedes fibrosis resolution. PMID: 27256716
  7. Both fetal Tn-C variants may represent novel biomarkers that are capable of estimating both pulmonary vascular remodeling and right ventricular load. PMID: 29117120
  8. high TNC expression correlates with worse prognosis for lung adenocarcinoma and has a role in lung cancer progressoin PMID: 28652369
  9. Decellularized lung scaffolds treated with FBN-2 and TN-C prior to re-epithelialization supported greater epithelial proliferation and tissue remodeling. PMID: 28662401
  10. Immunohistochemical analysis shows that the unique association between the CD44+/CD24low/- phenotype and the pronounced production of tenascin C may have a prognostic potential, prospectively indicating the inefficiency of neoadjuvant polychemotherapy (PCT), in particular that with platinum derivatives, which is used for the standard treatment of triple-negative BC. PMID: 29027523
  11. Enhanced serum tenascin-C concentrations are closely related to trauma severity and clinical outcomes PMID: 28732652
  12. Functional studies showed THBS1 and TNC to mediate chemoresistance through the integrin beta1/mTOR pathway. PMID: 27487140
  13. Elevated Tenascin-C serum values are associated with non-small cell lung cancer. PMID: 26967391
  14. Tenascin-C was abundantly secreted by the colon cancer cells with high metastatic potential, and highly expressed in lymph nodes with metastasis. PMID: 27191989
  15. Intermittent hypoxia confers pro-metastatic gene expression selectively through NF-kappaB in inflammatory breast cancer cells, in particular, to tenascin-C and MPP9. PMID: 27717868
  16. Metastatic prostate cancer cells cultured on osteo-mimetic surfaces coated with tenascin C exhibited enhanced adhesion and colony formation as mediated by integrin alpha9beta1. PMID: 28916657
  17. Study showed that the proinflammatory, extracellular matrix glycoprotein tenascin-C from tissue damage and microbial lipopolysaccharide (LPS) from bacterial infection activated a common set of signaling pathways, including NF-kappaB and MAPK, but these stimuli also induced different signaling pathways downstream of TLR4. PMID: 27577261
  18. High Tenacin C expression is associated with liver metastasis in colorectal cancer stroma. PMID: 29065427
  19. Tenascin-C protein expression in this muscle was confined to arterioles and venules (80% of cases) and increased after training in A-allele carriers. Prior to training, volume densities of subsarcolemmal and myofibrillar mitochondria in m. vastus lateralis muscle were 49% and 18%, respectively, higher in A/A homozygotes relative to T-nucleotide carriers (A/T and T/T) PMID: 28384286
  20. Study that recombinant TNC consisting of the epidermal growth factor (EGF-like repeats induced cerebral arterial constriction via EGF receptor and activation of ERK1/2 PMID: 27086972
  21. Tenascin-C was abundant in cortical white and gray matter in brain tissue from Alzheimer's Disease patients. PMID: 27444354
  22. secreted by transdifferentiated retinal pigment epithelial cells and promotes the development of choroidal neovascularization via integrin alphaV in a paracrine manner PMID: 27668890
  23. Overexpression of TNC, SMA, and vimentin were significantly correlated with the lower overall survival in prostate cancer patients. PMID: 28341124
  24. analysis of SNPs in tenascin-C (TNC) associated with degenerative rotator cuff tears PMID: 27248364
  25. High TNC expression is associated with retinoblastoma. PMID: 27488116
  26. prepartum and postpartum TN-C serum levels significantly higher in mild and severe preeclampsia than in healthy pregnancy PMID: 25567561
  27. Tenascin-C overexpression in cancer cells and stromal fibroblasts was an independent poor prognostic factor for overall survival and disease-free survival esophageal squamous cell carcinoma patients. PMID: 26731558
  28. Serum TNC levels are significantly raised and correlate with various clinical and laboratory variables of disease activity in children with enthesitis-related arthritis PMID: 25774061
  29. This study has identified tenascin-C as a promoter of the invasiveness of brain tumor-initiating cells through a mechanism involving ADAM-9 proteolysis via the c-Jun NH2-terminal kinase pathway. PMID: 25646025
  30. Co-expression of Matrix metalloproteinase-9 and Tenascin-C was associated with poorer prognosis and was found to be an independent predictor of survival PMID: 26652622
  31. Studied the expression of TNC in tissue microarrays including 17 GBMs, 18 WHO grade III astrocytomas, 15 WHO grade II astrocytomas, 4 WHO grade I astrocytomas, and 7 normal brain tissue samples by immunohistochemical staining. PMID: 25469866
  32. No difference in tenascin-C expression was found in COPD. PMID: 25794567
  33. miR-133a enhances the protective capacity of cardiac progenitors cells after myocardial infarction PMID: 25448067
  34. A pivotal role for TNC in tuning the local immune response to establish equilibrium between disseminated nodal cancer stem cells and the immune system. PMID: 25808872
  35. lung cancer patients with Oct4 high, PTEN low and TNC high expression profile significantly correlated with poor disease-free survival PMID: 25609695
  36. Circulating concentrations of Tn-C are higher in patients with a recent history of atherosclerotic stroke and may play an anti-inflammatory role by reducing pro-inflammatory cytokine release from atheroma. PMID: 24823872
  37. Data indicate the expression of fetal ED-A(+) fibronectin and B (+) tenascin-C splicing variants in cardiac tissue from heart transplant recipients. PMID: 24792713
  38. Tn-C and Gl-3 are promising markers for the diagnosis of pulmonary sarcoidosis, but they are not specific for cardiac involvement. PMID: 24777587
  39. Subraracnoid hemorrhage, aneurysmal that is more severe induces more TNC, which may cause the subsequent development of both vasospasm and vasospasm-unrelated secondary brain injury, leading to ischemia. PMID: 25366610
  40. The coated combination of TnC and TnR appeared to regulate neural differentiation signaling through integrin alpha7 and alpha9beta1 in bone marrow-derived human mesenchymal stem cells. PMID: 24829055
  41. the fibronectin type III-like repeats in tenascin-C may be playing an important role in PCO. PMID: 25515583
  42. Results found that Tenascin-C FNIIIA1 is over-expressed in osteosarcoma tissues and can promote MG-63 cell migration suggesting that high expression of A1 may promote metastasis of osteosarcoma. PMID: 24598996
  43. Demonstrate that tenascin-C level is associated with pathologic conditions in acute coronary syndrome, especially the presence of ruptured plaque. PMID: 23532307
  44. Interleukin-1-induced changes in the glioblastoma secretome suggest its role in tumor progression. PMID: 24503185
  45. In conclusion, although serum TNC levels are elevated, it has no predictive or prognostic roles on survival in breast cancer patients. PMID: 24696262
  46. although serum TNC levels are elevated, it has no predictive or prognostic roles on survival in epithelial ovarian cancer patients. PMID: 24722824
  47. Tenascin-C-derived peptide TNIIIA2 highly enhances cell survival and platelet-derived growth factor (PDGF)-dependent cell proliferation through potentiated and sustained activation of integrin alpha5beta1. PMID: 24808173
  48. Studied serum levels of Tn-C containing the FNIIIB (B+ Tn-C) or FNIIIC (C+ Tn-C) domain in heart failure patients. Analysis of Tn-C concentrations according to heart failure etiology revealed no significant differences. PMID: 25016707
  49. serum levels elevated in scleroderma PMID: 23834524
  50. Serum levels of MMP-9, TIMP-1 and B(+) Tn-C and tissue levels of B(+) Tn-C and ED-A(+) Fn are promising markers for risk assessment in dilated cardiomyopathy. PMID: 23998545
  51. Serum levels of tenascin-C are elevated in type B acute aortic dissection. PMID: 23742930
  52. The study shows that Tenascin-C is expressed by human glioma in vivo and shows a strong association with tumor blood vessels. PMID: 23963648
  53. Taken together,these findings suggest that growth factors and mechanical strain can induce TN-C in osteosarcoma through different pathways additively. PMID: 24063281
  54. Exome sequencing and linkage analysis identified tenascin-C (TNC) as a novel causative gene in nonsyndromic hearing loss. PMID: 23936043
  55. Tenascin-C expression in esophageal squamous carcinoma cells may in part explain why C4.4A is associated with a poor prognosis of esophageal squamous carcinoma since TNC can promote invasion and metastasis. PMID: 23708783
  56. Tenascin-C is a marker of progressive destabilization of the aortic wall independent of size in chronic dilatation and acute dissection. PMID: 23656926
  57. Tenascin-C is an innate broad-spectrum, HIV-1-neutralizing protein in breast milk. PMID: 24145401
  58. The promiscuous yet high affinity of TNC for a wide array of growth factors, mediated mainly by TNCIII5, may play a role in multiple physiological and pathological processes involving TNC. PMID: 23637968
  59. IL-1alpha reduces CCN2 expression and increased TNC expression in human cardiac fibroblasts. PMID: 23454256
  60. TNC does not appear to contribute directly to outflow resistance in the eye. PMID: 23882691
  61. TnC and TnR play important roles in nervous and immune systems. [Review] PMID: 23269478
  62. The interaction of aptamer GBI-10 with TN-C depended on the presence of Mg(2)+. PMID: 23280617
  63. Progression of urothelial carcinoma of the urinary bladder with time is accompanied by significant changes in urinary levels of B(+) Tn-C PMID: 21763295
  64. High tenascin-C expression is associated with colorectal cancer. PMID: 23645740
  65. The interaction of TNC with immobilized FN was attenuated, the scratch wound closure by keratinocytes was delayed and the inhibition of cell spreading on FN by TNC was recovered in the presence of SSL8. PMID: 23485472
  66. This study further implicates the genomic region containing the TNC and COL27A1 genes in influencing risk of Achilles tendinopathy, and maps the potential risk allele to a genetic interval flanked by rs946053 and rs2104772. PMID: 23192621
  67. these findings suggest that melanoma-derived TNCEGFL exert a role in melanoma invasion by modulating ROCK signaling and cell migration. PMID: 22951722
  68. In view of its specific expression, TN-C could be a realistic and promising biomarker and a target for molecular imaging for the diagnosis of various cardiovascular diseases. PMID: 23064399
  69. The present results demonstrated that the bronchoalveolar lavage fluid tenascin-C level was correlated with pulmonary infiltrates on chest radiographs in patients with sarcoidosis. PMID: 22760918
  70. Dermal expression of tenascin-C in the vitiligenous lesion may be linked to the disease more than epidermal expression. PMID: 22495383
  71. TNC is involved in the etiopathology of obesity via visceral adipose tissue inflammation representing a link with extracellular matrix remodeling. PMID: 22851489
  72. TNC produced by oxLDL-stimulated macrophages increases foam cell formation through TLR4 and scavenger receptor CD36. PMID: 22699754
  73. High tenascin-C is associated with the invasive phenotype of low-grade astrocytoma. PMID: 21997179
  74. Increased expression of tenascin-C was observed in sites of epithelial-mesenchymal interaction and loss of cell-cell adhesion was assessed in translocated epithelial cells in the stroma. PMID: 21885141
  75. TN-C expression in knee cartilage and TN-C levels in synovial fluid are both enhanced in osteoarthritis patients. Elevated levels of TN-C induce inflammatory mediators and promote matrix degradation in osteoarthritic joints. PMID: 21762512
  76. a soluble human TNFR2 agonist (TNC-scTNF(R2)) rescues human neurons from oxidative stress-induced cell death PMID: 22110694
  77. TN-C may be a useful biomarker for indicating the pathological status of smooth muscle cells and interstitial cells in abdominal aortic aneurysm. PMID: 21951663
  78. NB tumors two putative niches containing Oct-4(+) tumor cells. Oct-4(+)/TNC(+) perivascular NB cells displayed a high degree of plasticity and served as progenitors of TECs. PMID: 21403679
  79. Thrombin-cleaved forms of sOPN and TN-C share a common integrin receptor, alpha9beta1, and alpha9beta1 integrin-mediated signaling is involved in the pathogenesis of various autoimmune diseases. PMID: 21501293
  80. Tenascin-C is likely involved in the fibrosis that occurs around collecting ducts in chronic sclerosing sialadenitis PMID: 21559807
  81. TNC in the cerebrospinal fluid may be a useful biomarker for predicting subsequent development of cerebral vasospasm PMID: 21862932
  82. we have identified alpha(9) integrin-mediated signaling by TN-C and OPN as a novel intrinsic regulator of pathogenic Th17 cell generation that contributes to the development of rheumatoid arthritis. PMID: 22039306
  83. higher tenascin-C levels are related to the total occlusion and inflammation after myocardial infarction PMID: 21512282
  84. Kinetic partitioning mechanism governs the folding of the third FnIII domain of tenascin-C. PMID: 21839747
  85. High Tenascin-C is associated with acute pulmonary thromboembolism. PMID: 21350305
  86. Demonstrate increased expression of tenascin-C and alpha-smooth muscle actin positive cells in the large airways in chronic obstructive pulmonary disease. PMID: 21496259
  87. SNP rs12347433 is a synonymous coding SNP and may be biologically relevant to the mechanism by which tenascin-C influences the pathophysiology of CAD and atherosclerosis PMID: 21298289
  88. plasma large splice variant levels of tenascin-C are independently associated with cardiovascular outcomes in CKD patients. PMID: 21183183
  89. TNC could induce EMT-like change showing loss of intercellular adhesion and enhanced migration in breast cancer cells, associated with FAK phosphorylation by SRC PMID: 21281808
  90. Tenascin-C contains cryptic sites which can control tissue levels of fibrillar fibronectin either by preventing de novo fibril assembly or reducing levels of deposited fibronectin. PMID: 20708078
  91. Type-II alveolar epithelial cells from three types of Idiopathic interstitial lung diseases express tenascin-C. PMID: 21039988
  92. Up-regulated expression of TNC in nasal polyp tissues is related to eosinophil-derived TGF-beta1. PMID: 16144346
  93. Data suggest a highly significant association between AD-containing TNC isoforms and breast cancers in younger women (age PMID: 20678196
  94. Study provides evidence that TN-C serves as a novel adhesive matrix for platelets in a context that is relevant to atherothrombosis. PMID: 20651280
  95. Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population. PMID: 20729912
  96. Microarray analysis showed that TNC was highly expressed in early osteogenesis. PMID: 20613589
  97. The combination of an increased expression of the antimicrobial peptide DEFA-4, the oncogene S100-A7, epidermal growth factor, and tenascin-c, and a decreased Doc-1 expression in oral leukoplakia might characterize its potency of malignant transformation. PMID: 20727496
  98. Expression of tenascin-c and integrin beta3 decrease the expression of uPA through p38 MAPK in breast neolasms. PMID: 21091771
  99. Differential gene expression in classic giant cell tumours of bone: Tenascin C as biological risk factor for local relapses and metastases. PMID: 20653781
  100. An increased expression of fibronectin and tenascin-C mRNA in association to histological damage and in valvular heart disease compared to coronary artery disease could be shown. PMID: 20232238

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Involvement in disease Deafness, autosomal dominant, 56 (DFNA56)
Subcellular Location Secreted, extracellular space, extracellular matrix
Protein Families Tenascin family
Database Links

HGNC: 5318

OMIM: 187380

KEGG: hsa:3371

STRING: 9606.ENSP00000265131

UniGene: Hs.143250

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