Code | CSB-E04586h |
Size | 96T |
Price | Request a Quote or Start an on-line Chat |
Trial Size |
24T ELISA Kit Trial Size (Only USD$150/ kit) * The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now |
The product CSB-E04586h is a sandwich ELISA kit developed to measure concentrations of human IGFBP1 in serum, plasma, or tissue homogenates. This assay uses the sandwich enzyme immunoassay technique in combination with the enzyme-substrate chromogenic reaction to quantify the analyte in the sample. The color develops positively to the amount of IGFBP1 in samples. The color intensity is measured at 450 nm via a microplate reader.
IGFBP1 is produced dominantly in the liver, heart, and kidney. It binds to insulin-like growth factor (IGF) and regulates IGF actions in somatic growth, development, and aging. IGFBP-1 not only is an important determinant of IGF activity but also enhances glucose uptake in peripheral tissues and decreases glucose output in the liver. It regulates cell proliferation, migration, and glucose metabolism by activating integrin-ILK/FAK/PTEN signaling through integrin receptors on the cell membrane. Low circulating levels of IGFBP1 are related to insulin resistance and predict the development of type 2 diabetes. Dysregulation of IGFBP1, as well as IGFs in serum and cervical secretions, induces metabolic disease and cardiovascular disease. Overexpression of IGFBP1 has been shown to improve impaired glucose tolerance.
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