Mouse Stanniocalcin-1(STC1) ELISA kit

1. Latanoprost-induced reduction of intraocular pressure is mediated through the downstream signaling molecule STC-1. When used by itself, STC-1 exhibits ocular hypotensive properties. PMID: 28538979
2. STC-1 maybe improve anti-inflammation, anti-oxidant and anti-apoptosis activities by affecting reactive oxygen species -mediated pathways, especially the phospho-modifications of the respective proteins, resulting in the increase of Superoxide dismutase and reduce of capase-3, p53, IL-6 and IFN-gamma. PMID: 27420048
3. STC1 blunts bleomycin-induced rise in thrombin protein and activity, diminishes thrombin-induced signaling through PAR1 to ERK, and inhibits bleomycin-induced pneumonitis. PMID: 26640170
4. Stanniocalcin 1 is expressed in thyroid side population cells and thyroid cancer cells. PMID: 25647164
5. Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using Stc1. PMID: 25373521
6. Stanniocalcin-1 inhibits renal ischemia/reperfusion injury via an AMP-activated protein kinase-dependent pathway. PMID: 25012175
7. STC1 is an endogenous stress protein that may counteract LPS-induced lung injury by inhibiting the inflammatory cascade and inducing antioxidant and antiapoptotic mechanisms. PMID: 24685991
8. critical for kidney tubular epithelial survival under physiologic conditions PMID: 24700878
9. Remarkably, X-linked genes are not overexpressed in female Stc1(-/-) mice, revealing the existence of a mechanism(s) that can compensate for a persistent XCI deficiency to regulate X-linked gene expression. PMID: 25136103
10. Overexpression of stanniocalcin-1 inhibits reactive oxygen species and renal ischemia/reperfusion injury. PMID: 22695329
11. STC1 was not crucial for the development of ischemic tolerance triggered by hypoxic preconditioning, or for preserving blood-brain barrier integrity but may be involved in functional recovery after stroke. PMID: 23159313
12. the inner medullary STC-1 gene is differentially regulated in rat and mouse by arginine vasopressin and angiotensin II PMID: 21867741
13. Vascular endothelial growth factor-D stimulates endothelial cell VEGF-A, stanniocalcin-1, and neuropilin-2 and has potent angiogenic effects. PMID: 21474827
14. STC-1 could have a role in salt and water balance as dehydration necessitates water conservation as well as controlled natriuresis and kaliuresis. PMID: 20540985
15. the biological repertoires of STCs in mammals will be considerably larger than in fish and may not be limited to mineral metabolism PMID: 11832417
16. STC1 is expressed in a time- and cell-specific manner and may play an autocrine/paracrine role during osteoblast development and bone formation PMID: 11897801
17. STC-1 can affect calcium homeostasis, bone and muscle mass and structure, and angiogenesis PMID: 12193584
18. Data characterize the STC receptor and the functional targeting of ligand and receptor to mitochondria. PMID: 12223480
19. STC1 may play a selective modulatory role in angiogenesis, possibly serving as a "stop signal" or stabilizing factor contributing to the maturation of newly formed blood vessels PMID: 14500721
20. role for mammalian STC1 in modulating the immune/inflammatory response in ureteric obstruction PMID: 14570698
21. kinetics of upregulated STC-1 expression during adipogenesis was investigated in 3T3-LI cells PMID: 15149855
22. These findings have thus shown that the mammary glands are indeed targeted by STC, even in the virgin state. PMID: 16150955
23. Stc1 function is not essential for growth or reproduction in the mouse PMID: 16287871
24. systemically derived STC-1 has important effects on mammary gland development and the transfer of serum-based triglycerides into milk and also has a role in maternal behavior PMID: 16772321
25. Hypoxic preconditioning leads to neuroprotection through IL-6-mediated upregulation of stanniocalcin-1 expression. PMID: 17272771
26. IL-6-induced expression of STC-1 is one molecular mechanism behind the ischemic tolerance generated by HOPC in the heart PMID: 17573464
27. stanniocalcin-1 is a potent anti-inflammatory and renal protective protein. PMID: 19246645
28. Stc1 acts in a negative feedback loop in the prosurvival ERK1/2 signaling pathway during oxidative stress. PMID: 19347030
29. Stanniocalcin-1 suppresses superoxide generation in macrophages through induction of mitochondrial UCP2. PMID: 19602668
30. Transgenic overexpression of hSTC1 results in severe post-natal dwarfism (30-50%) indepedent of GH or IGF-I and a reduction female reproductive competence. PMID: 11861508

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KEGG: mmu:20855

STRING: 10090.ENSMUSP00000014957

UniGene: Mm.20911