Mouse Transforming growth factor beta receptor type 3(TGFBR3) ELISA kit

1. TGFbetaR3 promotes apoptosis of cardiomyocytes via a p38 pathway-associated mechanism, and loss of TGFbetaR3 reduces myocardial infarction injury. PMID: 28559372
2. describe a detailed characterization of TbetaRIII expression in lymphocyte subpopulations demonstrating that this co-receptor is significantly expressed in T but not B lymphocytes and among them, preferentially expressed on naive and central memory T cells PMID: 29050936
3. Study identified a novel major binding site for TGF-beta-like growth factors in TGFR-3. Findings potentially provide novel experimental insight into the general function of zona pellucida domain-containing proteins. PMID: 23826237
4. a signaling pathway important in epicardial cell behavior downstream of TGFbetaR3 PMID: 27505173
5. Retinoic acid enhanced TbetaRIII expression and that this increase contributed to LF-stimulated IgA production. PMID: 26277894
6. These data reveal a critical, previously unrecognized role for TGFbetaR3 in vascular and osteoblast development during palatogenesis. PMID: 25382630
7. These data demonstrate that TbetaRIII regulates BMP-mediated signaling and biological effects, primarily through the ligand sequestration effects of sTbetaRIII in normal and cancerous mammary epithelial cells. PMID: 25077702
8. TGFBR3 mediated suppression of cancer progression includes effects on the tumor immune microenvironment. PMID: 23925295
9. Loss of Tgfbr3 compromises the functions of TGFbeta2 in the differentiating fetal testis. PMID: 23303681
10. A novel reciprocal loop between miR-21 and TGFbetaRIII in cardiac fibrosis caused by myocardial infarction in mice. PMID: 22960625
11. These data suggest that Inhibins and TbetaRIII may function as a molecular pair regulating T cell development. PMID: 22952931
12. the relative roles of TGFbetaR3-dependent and -independent signaling in the actions of BMP2 on epicardial cell behavior and demonstrate the critical role of TGFbetaR3 in mediating BMP2-stimulated invasion. PMID: 22237159
13. used intact embryos and epicardial cells from E11.5 mouse embryos to reveal the mechanisms by which TGFbetaR3 signals and regulates epicardial cell behavior PMID: 21871877
14. TGFBR3 can prevent hypoxia-induced injury in neonatal mice cardiac fibroblasts by negative regulation of TGF-beta signaling. PMID: 21792916
15. Data present the 2.0-A resolution crystal structure of the betaglycan ZP-C region in combination with a downstream region known as the external hydrophobic patch. PMID: 21402931
16. Tgfbr3 is associated with acute lung injury PMID: 21297076
17. TbetaRIII enhanced both ALK3 & ALK6 signaling. TbetaRIII mediates differential ALK3 and ALK6 subcellular trafficking resulting in distinct signaling downstream of ALK3 and ALK6. PMID: 19726563
18. required for normal seminiferous cord formation, normal fetal Leydig cell development, and the establishment of fetal testis endocrine function PMID: 19696014
19. These results indicate that betaglycan expression is up-regulated during myogenesis and that MyoD and RA modulate its expression by a mechanism that is independent of myogenin. PMID: 12399463
20. TbetaRIII is an important modulator of TGFbeta2 function in embryonic fibroblasts and reduced sensitivity to TGFbeta2 may underlie aspects of the TbetaRIII mutant phenotype PMID: 12773577
21. TbetaRIII is not required for TGF-beta2 to signal when sufficient TGF-beta2, TbetaRI, and TbetaRII or TbetaRII-B are present PMID: 14996829
22. TbetaRIII appeared to inhibit mammary tumor invasion by undergoing ectodomain shedding and producing soluble TbetaRIII. PMID: 17160136
23. Tgfbr3 is required for coronary vessel development and embryonic viability. PMID: 17704211
24. These data indicate that TbetaRIII acts as a tumor suppressor in nontumorigenic mammary epithelial cells at least in part by inhibiting NFkappaB-mediated repression of E-cadherin. PMID: 17823118
25. Pronounced changes in the expression and localization of the TGF-beta receptors Tgfbr3 were noted as mouse lungs progressed through the canalicular, saccular, and alveolar stages of development. PMID: 18095342
26. expressed at higher levels in the developing testis compared to ovary PMID: 18236212
27. These results demonstrated that endocrine effects of inhibin as a negative feedback controller of follicle stimulating hormone production in gonadotropes are dependent on betaglycan expression. PMID: 19524135

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KEGG: mmu:21814

STRING: 10090.ENSMUSP00000031224

UniGene: Mm.200775