Rat Collagen alpha-1(I) chain (COL1A1) ELISA kit

Code CSB-E12732r
Size 96T,5×96T,10×96T How to order?
Trial Size 24T ELISA kits trial application
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Product Details

Description

The rat collagen alpha-1 chain (COL1A1) ELISA Kit is used to quantitatively measure rat COL1A1 concentrations in serum, plasma, or tissue homogenates. It performs well in important characteristics, including sensitivity and specificity. This assay is based on the sandwich ELISA mechanism and enzyme-substrate chromogenic reaction. The solution color develops proportionally to the amount of COL1A1 in the sample. And the intensity of the color can be measured at 450 nm via a microplate reader.

COL1A1 is a major component of collagen type I. It has recently been found that COL1A1 is overexpressed in a variety of tumor tissues and cells such as hepatocellular carcinoma (HCC). Mutations in COL1A1 can cause collagen-related diseases, including autosomal dominant osteogenesis imperfecta (OI) and the rare arthrochalasis subtype of Ehlers-Danlos syndrome (EDS). Liu J et al. have demonstrated that a high level of COL1A1 is indicative of a more aggressive cellular behavior and poorer prognosis in patients with breast cancer, especially in those with ER+ breast cancer.

Target Name collagen, type I, alpha 1
Alternative Names COL1A1Collagen alpha-1(I) chain ELISA kit; Alpha-1 type I collagen ELISA kit; Fragment ELISA kit
Abbreviation COL1A1
Uniprot No. P02456
Species Rattus norvegicus (Rat)
Sample Types serum, plasma, tissue homogenates
Detection Range 0.156 ng/mL-10 ng/mL
Sensitivity 0.039 ng/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Signal Transduction
Assay Principle quantitative
Measurement Sandwich
ELISA Data Analysis Watch ELISA data processing video & download Curve Expert if needed
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

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Target Background

Function
(From Uniprot)
Type I collagen is a member of group I collagen (fibrillar forming collagen).
Subcellular Location Secreted, extracellular space, extracellular matrix.
Protein Families Fibrillar collagen family
Tissue Specificity Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.
Database Links

UniGene: Ocu.3445

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