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Rat Collagen alpha-1(I) chain (COL1A1) ELISA kit

Rat Collagen alpha-1(I) chain (COL1A1) ELISA kit

Citations (2) Protocol MSDS

Code	CSB-E12732r
Size	96T,5×96T,10×96T
Price	Request a Quote
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Product Details
Citations (2)
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Target Name

collagen, type I, alpha 1

Alternative Names

COL1A1Collagen alpha-1(I) chain ELISA kit; Alpha-1 type I collagen ELISA kit; Fragment ELISA kit

Abbreviation

COL1A1

Uniprot No.

P02456

Species

Rattus norvegicus (Rat)

Sample Types

serum, plasma, tissue homogenates

Detection Range

0.156 ng/mL-10 ng/mL

Sensitivity

0.039 ng/mL

Assay Time

1-5h

Sample Volume

50-100ul

Detection Wavelength

450 nm

Research Area

Signal Transduction

Assay Principle

quantitative

Measurement

Sandwich

ELISA Data Analysis

ELISA Standard Curve & Curve Expert software

Troubleshooting
and FAQs

ELISA kit FAQs

Storage

Store at 2-8°C. Please refer to protocol.

Shelf Life

6 months

Lead Time

3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx.

Description

The rat collagen alpha-1 chain (COL1A1) ELISA Kit is used to quantitatively measure rat COL1A1 concentrations in serum, plasma, or tissue homogenates. It performs well in important characteristics, including sensitivity and specificity. This assay is based on the sandwich ELISA mechanism and enzyme-substrate chromogenic reaction. The solution color develops proportionally to the amount of COL1A1 in the sample. And the intensity of the color can be measured at 450 nm via a microplate reader.

COL1A1 is a major component of collagen type I. It has recently been found that COL1A1 is overexpressed in a variety of tumor tissues and cells such as hepatocellular carcinoma (HCC). Mutations in COL1A1 can cause collagen-related diseases, including autosomal dominant osteogenesis imperfecta (OI) and the rare arthrochalasis subtype of Ehlers-Danlos syndrome (EDS). Liu J et al. have demonstrated that a high level of COL1A1 is indicative of a more aggressive cellular behavior and poorer prognosis in patients with breast cancer, especially in those with ER+ breast cancer.

Citations

Lentiviral Vector-Mediated FoxO1 Overexpression Inhibits Extracellular Matrix Protein Secretion Under High Glucose Conditions in Mesangial Cells. Guo F.et al,J Cell Biochem.,2016
iTRAQ-based proteomic analysis of combination therapy with taurine, epigallocatechin gallate, and genistein on carbon tetrachloride-induced liver fibrosis in rats. Cao W.et al,Toxicol Lett.,2015

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Target Background

Function
(From Uniprot)

Type I collagen is a member of group I collagen (fibrillar forming collagen).

Subcellular Location

Secreted, extracellular space, extracellular matrix.

Protein Families

Fibrillar collagen family

Tissue Specificity

Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.

Database Links

UniGene: Ocu.3445

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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Rat Collagen alpha-1(I) chain (COL1A1) ELISA kit

Product Details

Citations

Related Products

Customer Reviews and Q&A

Target Background