Recombinant Human Interleukin-11 protein(IL11) (Active)

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Code CSB-AP001801HU
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Product Details

Purity >95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine B9-11 cells is less than 1 ng/ml, corresponding to a specific activity of >1.0x106 IU/mg.
Target Names IL11
Uniprot No. P20809
Research Area Immunology
Alternative Names Adipogenesis inhibitory factor; AGIF; IL 11; IL-11; Il11; IL11_HUMAN; Interleukin 11; Interleukin-11; Oprelvekin
Species Homo sapiens (Human)
Source E.coli
Expression Region 22-199aa
Complete Sequence M+PGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL
Mol. Weight 19.1 kDa
Protein Length Full Length of Mature Protein
Tag Info Tag-Free
Form Lyophilized powder
Buffer Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production
Gene References into Functions
  1. the identification of a dysregulated miR-124/IL-11 axis helps elucidate mechanisms of breast cancer metastases to bone, uncovers new prognostic markers, and facilitates the development of novel therapeutic targets to treat and even prevent bone metastases of breast cancer. PMID: 29343249
  2. The results indicate that miR-23b regulates IL-11 and IL-11Ralpha expression, and it might act as an anti-oncogenic agent in the progression of Hepatocellular Carcinoma by directly downregulating IL-11 expression. PMID: 29901200
  3. It has been concluded that the renal cell carcinoma risk allele at 12p12.1 maps to rs7132434, a functional variant in an enhancer that upregulates BHLHE41 expression which, in turn, induces IL-11, a member of the IL-6 cytokine family. PMID: 27384883
  4. The results indicated that miR-124a has an important role as a tumor suppressor gene by targeting IL-11. PMID: 29286137
  5. Studied the role of ZEB1-AS1, and it's association with IL-11, in promoting STAT3 activation in B-lymphoblastic leukemia. PMID: 28861713
  6. Cancer-associated fibroblasts treated with cisplatin facilitate chemoresistance of lung adenocarcinoma through IL-11/IL-11R/STAT3 signaling pathway. PMID: 27922075
  7. results reveal a central role of IL-11 in fibrosis and we propose that inhibition of IL-11 is a potential therapeutic strategy to treat fibrotic diseases PMID: 29160304
  8. up-regulates GRP78 in the placenta PMID: 28487027
  9. The identification of the miR-206/TWF1/MKL1-SRF/IL11 signaling pathway sheds lights on the understanding of breast cancer initiation and progression, unveils new therapeutic targets, and facilitates innovative drug development to control cancer and block metastasis PMID: 27435395
  10. This review will discuss the available structural, functional, and bioinformatics knowledge concerning IL-11 and will summarize its relationship with several diseases PMID: 27312790
  11. Authors found a significant correlation between NRF2 and IL-11 status in breast cancer patients. Based on a recent report demonstrating that IL-11 is induced downstream of NRF2, authors examined the significance of IL-11 in NRF2-driven tumorigenesis with a newly established NRF2 addiction cancer model. PMID: 28714957
  12. this study shows that recombinant IL-11 is effective with tolerable adverse effects in Chinese patients with autoimmune thrombocytopenic purpura PMID: 27235596
  13. HMGA2 promoted colorectal cancer metastasis and epithelial-mesenchymal transition via activation of the FN1 and IL11/STAT3 signaling pathways. PMID: 26964871
  14. Together, these results suggest that the IL-11/STAT3 signaling pathway plays a critical role in human chronic atrophic gastritis , and may provide new targets to prevent and treat gastric cancer PMID: 27173233
  15. Proteolysis of the IL-11R represents a molecular switch that controls the IL-11 trans-signaling pathway which is the target in intestinal tumorigenesis, lung carcinomas, and asthma. PMID: 26876177
  16. IL-11 has a protective role and can accelerate recovery of platelets, and remarkably lessen the extent of inflammatory responses, hence reducing the mortality in sepsis patients accompanied with thrombocytopenia. PMID: 26276375
  17. Results indicate that iterleukin-11 (IL11) is causal of Preeclampsia (PE) features in a mouse model and likely in women, and suggest potential of IL11 inhibition to rescue PE symptoms in women. PMID: 26655736
  18. The cross-talk between Th17 and interleukin 11 (IL-11+)CD4+ T cells may induce and amplify the autoimmune response in the early stage of multiple sclerosis (MS), and thus represent an attractive therapeutic target in this and other inflammatory diseases. PMID: 26452137
  19. Genetic variations of IL-11 may be associated with the risk of Hirschsprung disease and/or the mechanisms related to enteric nervous system development. PMID: 26172388
  20. IL-11 expression in breast cancer correlates with poor disease outcome PMID: 26209885
  21. data offer insight into the binding interactions of IL-11 with each of its receptors and the structural mechanisms underlying agonist and antagonist variants of the protein PMID: 25195742
  22. The highly specific IL-11 - S100P interaction occurring under physiologically relevant conditions should be taken into consideration upon development of the antineoplastics inhibiting IL-11 signaling. PMID: 26551460
  23. MTA2 overexpression enhances colony formation and tumor growth of gastric cancer cells, but not plays important role in cancer cell migration and metastasis. IL-11 is one of the downstream effectors of MTA2 in regulating gastric cancer cells growth PMID: 25929737
  24. IL-11 stimulates BSP gene transcription. PMID: 24633490
  25. The results prove the presence of the potentially functionally relevant IL-11 gene variants in the population of infertile women. PMID: 24635366
  26. High expression of interleukin-11 correlated with poor prognosis in clear-cell renal cell carcinoma patients. PMID: 25702890
  27. IL-11 is identified as a new Th17-promoting cytokine, because it induces a differentiation of naive CD4(+) T cells into Th17 cells, as well as expansion of Th17 memory cells. PMID: 25895532
  28. Low serum interleukin-11 are associated with pancreatic cancer. PMID: 25123265
  29. Pretreatment with rhIL-11 can reduce galactosamine-induced acute liver failure and protect the liver. PMID: 24817287
  30. In the presence of 100 ng/ml IL-11, GATA-3 transcript abundance rose up to ~85-fold of that measured in untreated cells, whereas T-bet transcripts were lowered merely to ~41% PMID: 24338248
  31. It Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a significant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion. PMID: 23631681
  32. DNA methylation of the CpG island in the IL-11 gene is associated with response of major depressive disorder patients to antidepressant drugs. PMID: 24002086
  33. IL-11 is associated with bone metastasis. PMID: 23813018
  34. IL11 given orally protects the intestinal mucosa from radiation damage PMID: 24219324
  35. IL-11 therefore drives a pathway that enhances HSPC radioresistance and radiation-induced B-cell malignancies, but is normally attenuated by the inhibitory adaptor Lnk. PMID: 24297922
  36. Solar simulted radiation-induced Il-11 may be involved in the photoaging-induced loss of facial subcutaneous fat. PMID: 23639700
  37. results suggest a two-step mechanism, whereby LfcinB induces TIMP-1 through an IL-11-dependent pathway involving transcription factor AP-1 and STAT3. PMID: 24036113
  38. induction of renal proximal tubule IL-11 is a critical intermediary in A1 adenosine receptor-mediated renal protection against acute ischemic kidney injury. PMID: 23813214
  39. the decreased ratio of IL-11/IL-17 might reflect an imbalance between the proinflammatory and anti-inflammatory cytokines in different periodontal diseases. PMID: 23226926
  40. An interleukin-6 family member, interleukin-11 is identified as a secondary target of twinfilin 1 in the microRNA-30c signalling pathway. PMID: 23340433
  41. Breast cancer cells may promote osteolysis in part by increasing the pool of osteoclast progenitor cells via tumor cell-derived IL-11. PMID: 23311882
  42. Enhanced production of IL-11 is associated with hepatocellular carcinoma metastasis to bone. PMID: 23307318
  43. IL11 is a hypoxia-inducible, VHL-regulated gene in human cancer cells and expression of IL11 mRNA is dependent, at least in part, on HIF-1. PMID: 23549086
  44. both the PI3K and Raf pathways are necessary for the expression of IL-11 in oncogenic Ras-mutated cells PMID: 23027619
  45. Data support the view that IL-11 is a key regulator of gastric damage acting to initiate chronic atrophic gastritis. PMID: 22180059
  46. IL-11 administration exhibits postconditioning effects through cardiac STAT3 activation, preventing myocardial ischemia-reperfusion injury. PMID: 22707562
  47. IL11 may be involved in endometrial cancer development PMID: 22614117
  48. Constructed a designer cytokine Hyper IL-11 (H11), which is exclusively composed of naturally existing components. It contains the full length sIL-11Ralpha connected with the mature IL-11 protein, and acts as an agonist on cells expressing the gp130 molec PMID: 22433466
  49. High Interleukin-11 is associated with multiple myeloma. PMID: 22289923
  50. Bovine lactoferrin administration prevented the progression of hepatic failure in human myofibroblasts and mice, and enhanced IL-11 and BMP2 expression in the small intestine. PMID: 21688123
  51. Exogenous IL-11 increased n gastric carcinoma cell line migration This was reversed when V0 & V1 expression was targeted by siRNA. Abnormally expressed versican participates in IL-11-triggered gastric carcinoma progression. PMID: 22393310
  52. High intratumoral CTGF and intratumoral IL-11 expression were associated with progression-free survival and overall survival after hepatectomy. PMID: 22205539
  53. IL-11 production was suppressed by capsazepine PMID: 22568077
  54. IL-11 provides a functional link between oxidative stress and compensatory proliferation PMID: 22253262
  55. skeletal myoblasts undergo apoptosis under oxidant stress in a time-dependent manner and preconditioning of skeletal myoblasts significantly prevented their apoptosis via IL-11/STAT3 signaling. PMID: 22168497
  56. Hyper-interleukin-11 novel designer molecular adjuvant directly targets gp130 leading to induction of specific and long lasting anticancer immune response. PMID: 21995459
  57. High interleukin-11 is associated with spontaneous basal ganglia haemorrhage. PMID: 21986128
  58. IL11 signaling is essential for the normal development of craniofacial bones and teeth, and its function is to restrict suture fusion and tooth number. PMID: 21741611
  59. demonstrated IL-11 expression by placental macrophages suggests that non-trophoblast cells contribute to IL-11 production at the maternal-fetal interface and thus account for the reproductive effects of the cytokine PMID: 20712807
  60. In some patients with chronic rhinosinusitis and coexisting osteitis IL11 gene expression in bone tissue is increased. PMID: 21442077
  61. Interleukin-11, an IL-6 like cytokine PMID: 21485496
  62. Non-core region modulates interleukin-11 signaling activity: generation of agonist and antagonist variants PMID: 21138838
  63. IL-11 suppresses glomerular expression of TGF-ss1 and extracellular matrix deposition in experimental glomerulonephritis. PMID: 20640990
  64. Serum concentrations of IL-6 family cytokines, including IL-6, IL-11, and LIF, were significantly elevated in patients with RA compared to those of healthy controls. PMID: 21155043
  65. IL11 is upregulated in gastric adenocarcinoma and is associated with tumor progression. PMID: 21443102
  66. hepatocyte growth factor and IL-11 are upregulated in Polycythemia vera and their overproduction is not a consequence of JAK2V617F PMID: 21042281
  67. Il11 as well as its receptor IL11RA are likely to play a role in the progression of endometrial carcinoma. PMID: 20553623
  68. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20360315
  69. increases invasiveness of JEG-3 choriocarcinoma PMID: 19716605
  70. Data shown that PROK1-PROKR1 induces the expression of IL-11 in PROKR1 Ishikawa cells and first trimester decidua. PMID: 19801577
  71. This study investigated the expression of IL-11 and role of prostaglandin F(2alpha)-F-prostanoid receptor (FP receptor) signaling in the modulation of IL-11 expression in endometrial adenocarcinoma cells. PMID: 20008143
  72. Studies indicate potential of LIF/IL11 as contraceptive targets and therapeutic agents for infertility. PMID: 19647472
  73. Interleukin-11 induces proliferation of human T-cells and its activity is associated with downregulation of p27(kip1). PMID: 11940481
  74. Administration of recombinant human IL11 after supralethal radiation exposure promotes survival in mice: interactive effect with thrombopoietin. PMID: 12005542
  75. IL-11 is involved in the endogenous cytokine response to sepsis or NEC in preterm neonates. PMID: 12032273
  76. Respiratory syncytial virus induces IL-11 generation in antigen presenting cells PMID: 12197884
  77. Dinucleotide repeat frequencies of the IL11.A1 allele and of IL11.A1 homozygous individuals is significantly increased among patients with ulcerative colitis. PMID: 12486609
  78. expression and function in human endometrium PMID: 12569176
  79. Recombinant human IL-11 induces from peripheral blood mononuclear cells the formation of osteoclastic cells, which are positive for tartrate-resistant acid phosphatase, vitronectin receptor and calcitonin receptor, and capable of lacunar resorption. PMID: 12584029
  80. Immunoreactive IL-11 & IL-11Ralpha were studied in human first trimester decidua & distinct spatial & temporal patterns were defined. IL-11 has a role during decidualization & placentation in primates. PMID: 12740032
  81. Upregulation of IL-11 mRNA by additive IL-1beta- and TGF-beta1, mediated by p38 MAP kinase-mediated mRNA stabilization. PMID: 12760902
  82. IL-11 exerts a cytoprotectve effect in a model of human T-cell mediated allograft rejection that is dependent on induction of survivin in graft endothelial cells. PMID: 14734714
  83. could have a significant role in the progression of gingivitis to periodontitis PMID: 15025215
  84. IL-11 produced by blastic cells from a patient with acute megakaryocytic leukemia enhanced expression of osteoprotegerin, causing the osteosclerosis observed in this patient. PMID: 15307108
  85. RANKL treatment induced a significant increase of IL-11 secretion by both bone marrow stromal & endothelial cells. PMID: 15377473
  86. production of IL-11 does not increase in response to thrombocytopenia in most children with SAA PMID: 15381181
  87. activation of three major signaling pathways and support a role for IL-11 in the regulation of both transcription and protein synthesis in fully differentiated adipocytes. PMID: 15389536
  88. LCH represents a cytokine-driven condition partially mediated by TNF, IL-11, and LIF. These three cytokines are all osteoclastogenic, suggesting a pathogenetic pathway for the osteolytic lesions in LCH. PMID: 15543003
  89. IL-11 expression is critically important during decidualization in the human endometrium PMID: 15613426
  90. in contrast to IL-6, IL-11 in plasma does not correlate with trauma severity PMID: 15614128
  91. Blocking IL-11 signaling reduced RLrelaxin and medoxyprogesterone or PGE(2)+P-induced decidualization. PMID: 15784719
  92. in human lung fibroblasts ET-1 exerts a profibrogenic action via an ET(A) receptor-dependent, MAPK-mediated induction of IL-11 release and cell proliferation PMID: 16149067
  93. High interleukin 11 is associated with breast cancer PMID: 16614887
  94. role for IL-11 via pSTAT3 and SOCS3 in initiating and progressing decidualization PMID: 16709613
  95. thrombocytopenia in dengue disease is associated with changes in the serum levels of thrombopoietin, but not interleukin-11 PMID: 16759877
  96. IL-11/IL-11R pathway plays an important role in the progression of colorectal adenocarcinoma. PMID: 16964382
  97. There is no receptivity defect with regard to LIF and IL-11 secretions by eutopic endometrium in infertile women with endometriosis. PMID: 17000646
  98. Increased IL-11 in premature senescence of fetal lung fibroblasts induced by both tert-butylhydroperoxide and ethanol. PMID: 17295091
  99. Role of interleukin-11 to prevent chemotherapy-induced thrombocytopenia. PMID: 17325843
  100. The objectives of this study were to clarify the role of IL-11 and IL-11Ralpha in human gastric carcinoma. PMID: 17332920

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Subcellular Location Secreted
Protein Families IL-6 superfamily
Database Links

HGNC: 5966

OMIM: 147681

KEGG: hsa:3589

STRING: 9606.ENSP00000264563

UniGene: Hs.467304

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